ZFIN ID: ZDB-GENE-090514-4
Gene Name: calcium channel, voltage-dependent, N type, alpha 1B subunit, b
Gene Symbol: cacna1bb    Nomenclature History

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Previous Names: si:dkeyp-23f6.1, si:dkeyp-23f6.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have voltage-gated calcium channel activity. Predicted to be involved in calcium ion import and chemical synaptic transmission. Predicted to localize to voltage-gated calcium channel complex. Is expressed in atrium and cardiac ventricle. Human ortholog(s) of this gene implicated in Lambert-Eaton myasthenic syndrome and dystonia 23. Orthologous to human CACNA1B (calcium voltage-gated channel subunit alpha1 B).
Genome Resources: Alliance (1),  Gene:562796 (1),  Ensembl(GRCz11):ENSDARG00000079295 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021815Tg Transgenic Insertion Unknown Unknown DNA
la021816Tg Transgenic Insertion Unknown Unknown DNA
la021817Tg Transgenic Insertion Unknown Unknown DNA
la021818Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa3120 Point Mutation Unknown Premature Stop ENU
    sa3131 Point Mutation Unknown Splice Site ENU
    sa29548 Point Mutation Unknown Premature Stop ENU
    sa32338 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32339 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37258 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43605 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44962 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH cacna1bb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with seizures and nonepileptic hyperkinetic movements 618497
    DISEASE ASSOCIATED WITH cacna1bb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process calcium ion transmembrane transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium channel activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cacna1bb-202 (1)    Ensembl 4311
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacna1bb No data available
    MARKER RELATIONSHIPS
    cacna1bb Contained in: [BAC] CH73-38J13 (1), CH73-73O13 (1), DKEYP-23F6 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_017352992 (1)
    Genomic GenBank:CR392036 (1) 145865 nt
    Select Tool
    Polypeptide UniProtKB:E7F278 (1) 2314 aa
    Sequence Information (all 25)
    ORTHOLOGY for cacna1bb ( Chr: 21 )
    CITATIONS (24)