ZFIN ID: ZDB-GENE-090514-3
Gene Name: calcium channel, voltage-dependent, P/Q type, alpha 1A subunit, b
Gene Symbol: cacna1ab    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: far (1), fakir (1), unm tb204, unm_tb204

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Exhibits high voltage-gated calcium channel activity. Involved in neuromuscular synaptic transmission; swimming behavior; and thigmotaxis. Predicted to localize to the voltage-gated calcium channel complex. Human ortholog(s) of this gene implicated in early infantile epileptic encephalopathy 42; hereditary ataxia (multiple); and migraine (multiple). Is expressed in Rohon-Beard neurons; atrium; cardiac ventricle; and spinal cord. Orthologous to human CACNA1A (calcium voltage-gated channel subunit alpha1 A).
Genome Resources: Alliance (1),  Gene:569528 (1),  Ensembl(GRCz11):ENSDARG00000006923 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la017844Tg Transgenic Insertion Unknown Unknown DNA
sa5845 Point Mutation Unknown Splice Site ENU
sa9062 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10764 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12516 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12560 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15403 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27809 Point Mutation Unknown Unknown ENU
    sa35120 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35121 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41872 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41873 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tb204a Point Mutation Unknown Missense
    tm154 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cacna1ab N/A 1
    DISEASE ASSOCIATED WITH cacna1ab HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    early infantile epileptic encephalopathy 42 Alliance Epileptic encephalopathy, early infantile, 42 617106
    episodic ataxia type 2 Alliance Episodic ataxia, type 2 108500
    familial hemiplegic migraine 1 Alliance Migraine, familial hemiplegic, 1 141500
    Migraine, familial hemiplegic, 1, with progressive cerebellar ataxia 141500
    spinocerebellar ataxia type 6 Alliance Spinocerebellar ataxia 6 183086
    DISEASE ASSOCIATED WITH cacna1ab VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process neuromuscular synaptic transmission (more)
    Cellular Component integral component of membrane (more)
    Molecular Function voltage-gated calcium channel activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR002048 EF-hand domain
    Domain IPR005821 Ion transport domain
    Domain IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain
    Domain IPR031649 Voltage-dependent L-type calcium channel, IQ-associated domain
    Family IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
    Homologous_superfamily IPR027359 Voltage-dependent channel domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cacna1ab-201 (1)    Ensembl 829
    cacna1ab-203 (1)    Ensembl 728
    cacna1ab-206 (1)    Ensembl 8383
    ncRNA cacna1ab-003 (1) 714
    cacna1ab-005 (1) 808
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cacna1ab No data available
    MARKER RELATIONSHIPS
    cacna1ab Contained in: [BAC] CH211-74A19 (1), CH211-200N13 (1), DKEY-69N2 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001328708 (1)
    Genomic GenBank:CR855274 (1) 173618 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IFN9 (1) 2319 aa
    Sequence Information (all 47)
    ORTHOLOGY for cacna1ab ( Chr: 11 )
    CITATIONS (41)