ZFIN ID: ZDB-GENE-090514-1
Gene Name: calcium channel, voltage-dependent, L type, alpha 1S subunit, a
Gene Symbol: cacna1sa    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cacna1s (1), cav1.1a1sa (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have high voltage-gated calcium channel activity. Predicted to be involved in calcium ion transport. Predicted to localize to voltage-gated calcium channel complex. Is expressed in atrium; cardiac ventricle; and somite. Human ortholog(s) of this gene implicated in hypokalemic periodic paralysis and malignant hyperthermia. Orthologous to human CACNA1S (calcium voltage-gated channel subunit alpha1 S).
Genome Resources: Alliance (1),  Gene:570683 (1),  Ensembl(GRCz11):ENSDARG00000029457 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 2 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Adult (90d-730d, breeding adult)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cacna1sa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypokalemic periodic paralysis Alliance Hypokalemic periodic paralysis, type 1 170400
{Malignant hyperthermia susceptibility 5} 601887
{Malignant hyperthermia, susceptibility to, 5} 601887
{Thyrotoxic periodic paralysis, susceptibility to, 1} 188580
DISEASE ASSOCIATED WITH cacna1sa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process NOT   calcium ion import (more)
Cellular Component integral component of membrane (more)
Molecular Function calcium channel activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cacna1sa-201 (1)    Ensembl 5650
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cacna1sa No data available
MARKER RELATIONSHIPS
cacna1sa Contained in: [BAC] CH73-352P18 (1)
[Fosmid] CH1073-119L24 (1), CH1073-487L8 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001146150 (1) 5484 nt
Genomic GenBank:FP067424 (1) 87896 nt
Select Tool
Polypeptide UniProtKB:C0LU14 (1) 1777 aa
Sequence Information (all 12)
ORTHOLOGY for cacna1sa ( Chr: 22 )
CITATIONS (30)