ZFIN Gene: smc1a

ZFIN ID: ZDB-GENE-090506-9

ZFIN ID: ZDB-GENE-090506-9

Gene Name:

structural maintenance of chromosomes 1A

Gene Symbol:

smc1a

Sequence Ontology ID :

SO:0001217

Previous Name:

sb:eu719

Location:

Chr: 23 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have ATP binding activity and chromatin binding activity. Involved in central nervous system development and developmental growth. Predicted to localize to the cohesin complex and ...

GENE EXPRESSION
All Expression Data:	3 figures from 2 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2005 [eu719]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
	central nervous system diencephalon hindbrain midbrain midbrain hindbrain boundary tail bud whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
sa32449	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa32450	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa44003	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Targeting reagents:

PHENOTYPE

Data:	3 figures from Fazio et al., 2016
Observed in:	central nervous system development head neural tube apoptotic process post-vent region whole organism

DISEASE ASSOCIATED WITH smc1a HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
Cornelia de Lange syndrome 2	Cornelia de Lange syndrome 2	300590

DISEASE ASSOCIATED WITH smc1a VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	developmental growth (more)
Cellular Component	chromosome (more)
Molecular Function	ATP binding (more)

GO Terms (all 10)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR003395 (1) InterPro:IPR010935 (1) InterPro:IPR024704 (1) InterPro:IPR027417 (1) InterPro:IPR029683 (1) InterPro:IPR036277 (1)	Pfam:PF02463 (1) Pfam:PF06470 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	smc1a-201 (1)	3745	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM smc1a No data available

MARKER RELATIONSHIPS

smc1a Contained in:	[BAC] DKEY-23G9 (1) (order this)
smc1a Encodes:	[EST] eu719 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001161631 (1)	3741 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR354431 (1)	46932 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:E7F0X6 (1)	1232 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:120420 (1)

Sequence Information (all 9)

OTHER smc1a GENE PAGES

Alliance (1)

Gene:559665 (1)

VEGA:OTTDARG00000028137 (1)

Ensembl(GRCz11):ENSDARG00000055754 (2)

ORTHOLOGY for smc1a ( Chr: 23 )

CITATIONS (18)

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