ZFIN ID: ZDB-GENE-090505-4
Gene Name: ER lipid raft associated 2
Gene Symbol: erlin2    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have cholesterol binding activity. Predicted to be involved in SREBP signaling pathway. Predicted to localize to endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 18. Orthologous to human ERLIN2 (ER lipid raft associated 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000095968 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:6907527]
High Throughput Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1659 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40490 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH erlin2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hereditary spastic paraplegia 18 Alliance Spastic paraplegia 18, autosomal recessive 611225
    DISEASE ASSOCIATED WITH erlin2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process SREBP signaling pathway (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function ubiquitin protein ligase binding (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ch25hl3-201 (1)    Ensembl 3869
    erlin2-201 (1)    Ensembl 774
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM erlin2 No data available
    MARKER RELATIONSHIPS
    erlin2 Contained in: [BAC] DKEY-204L11 (1) (order this)
    erlin2 Encodes: [EST] IMAGE:6907527 (1)
    erlin2 Has Artifact: [cDNA] MGC:91988
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:CB364130 (1) 514 nt
    Genomic GenBank:CR762390 (1) 167774 nt
    Select Tool
    Polypeptide UniProtKB:F6NPB1 (1) 258 aa
    ORTHOLOGY for erlin2 ( Chr: 5 )
    CITATIONS (20)