Gene
apc2
- ID
- ZDB-GENE-090422-1
- Name
- APC regulator of WNT signaling pathway 2
- Symbol
- apc2 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including cell fate specification; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of Wnt signaling pathway. Predicted to be located in several cellular components, including Golgi apparatus; microtubule cytoskeleton; and perinuclear region of cytoplasm. Predicted to be part of beta-catenin destruction complex and catenin complex. Predicted to colocalize with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; complex cortical dysplasia with other brain malformations; and nicotine dependence. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| autosomal recessive intellectual developmental disorder 74 | Alliance | Intellectual developmental disorder, autosomal recessive 74 | 617169 |
| complex cortical dysplasia with other brain malformations 10 | Alliance | Cortical dysplasia, complex, with other brain malformations 10 | 618677 |
| Sotos syndrome 3 | Alliance | Intellectual developmental disorder, autosomal recessive 74 | 617169 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR009234 | Adenomatous polyposis coli protein basic domain |
| Domain | IPR032038 | Adenomatous polyposis coli, N-terminal dimerisation domain |
| Family | IPR026818 | Adenomatous polyposis coli (APC) family |
| Homologous_superfamily | IPR011989 | Armadillo-like helical |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR026831 | Adenomatous polyposis coli protein |
| Homologous_superfamily | IPR036149 | APC, N-terminal coiled-coil domain superfamily |
| Repeat | IPR000225 | Armadillo |
| Repeat | IPR009223 | Adenomatous polyposis coli protein repeat |
| Repeat | IPR009224 | SAMP |
| Repeat | IPR041257 | Adenomatous polyposis coli (APC) repeat |
Domain Details Per Protein
| Protein | Additional Resources | Length | Adenomatous polyposis coli (APC) family | Adenomatous polyposis coli (APC) repeat | Adenomatous polyposis coli, N-terminal dimerisation domain | Adenomatous polyposis coli protein | Adenomatous polyposis coli protein basic domain | Adenomatous polyposis coli protein repeat | APC, N-terminal coiled-coil domain superfamily | Armadillo | Armadillo-like helical | Armadillo-type fold | SAMP |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M9QMA5 | InterPro | 2119 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance