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ZIRC
ZFIN ID: ZDB-GENE-090422-1
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Gene Name: APC regulator of WNT signaling pathway 2
Gene Symbol: apc2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have beta-catenin binding activity and gamma-catenin binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of microtubule depolymerization; and positive regulation of protein catabolic process. Predicted to colocalize with the cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Sotos syndrome. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).
Genome Resources: Alliance (1),  Gene:565771 (1),  Ensembl(GRCz11):ENSDARG00000063007 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa4406 Point Mutation Unknown Premature Stop ENU
sa12808 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa31814 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa41778 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH apc2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Cortical dysplasia, complex, with other brain malformations 10 618677
    ?Sotos syndrome 3 617169
    DISEASE ASSOCIATED WITH apc2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of canonical Wnt signaling pathway (more)
    Cellular Component beta-catenin destruction complex (more)
    Molecular Function beta-catenin binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000225 (1)
  • InterPro:IPR009223 (1)
  • InterPro:IPR009224 (1)
  • InterPro:IPR009234 (1)
  • InterPro:IPR011989 (1)
  • InterPro:IPR016024 (1)
  • InterPro:IPR026818 (1)
  • InterPro:IPR026831 (1)
  • InterPro:IPR026837 (1)
  • InterPro:IPR032038 (1)
  • InterPro:IPR036149 (1)
  • InterPro:IPR041257 (1)
  • PROSITE:PS50176 (1)
  • Pfam:PF00514 (1)
  • Pfam:PF05923 (1)
  • Pfam:PF05924 (1)
  • Pfam:PF05956 (1)
  • Pfam:PF16689 (1)
  • Pfam:PF18797 (1)
    • TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apc2-201 (1)    Ensembl 6450
    Select Tool
    Browsers: NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apc2 No data available
    MARKER RELATIONSHIPS
    apc2 Contained in: [BAC] DKEY-197I20 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021479985 (1)
    Select Tool
    Genomic GenBank:CR678040 (1) 119986 bp
    Select Tool
    Polypeptide UniProtKB:E7F064 (1) 2105 aa
    Select Tool
    Sequence Clusters UniGene:157812 (1)
    Sequence Information (all 9)
    ORTHOLOGY for apc2 ( Chr: 11 )
    CITATIONS (13)