apc2

ID

ZDB-GENE-090422-1

Name

APC regulator of WNT signaling pathway 2

Symbol

apc2 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including cell fate specification; negative regulation of canonical Wnt signaling pathway; and negative regulation of microtubule depolymerization. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of Wnt signaling pathway. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be part of beta-catenin destruction complex and catenin complex. Predicted to colocalize with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Sotos syndrome 3; autosomal recessive intellectual developmental disorder 74; complex cortical dysplasia with other brain malformations; and nicotine dependence. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apc2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
autosomal recessive intellectual developmental disorder 74	Alliance	Intellectual developmental disorder, autosomal recessive 74	617169
complex cortical dysplasia with other brain malformations 10	Alliance	Cortical dysplasia, complex, with other brain malformations 10	618677
Sotos syndrome 3	Alliance	Intellectual developmental disorder, autosomal recessive 74	617169

Associated With apc2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR009234	Adenomatous polyposis coli protein basic domain
Domain	IPR032038	Adenomatous polyposis coli, N-terminal dimerisation domain
Family	IPR026818	Adenomatous polyposis coli (APC) family
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR026831	Adenomatous polyposis coli protein
Homologous_superfamily	IPR036149	APC, N-terminal coiled-coil domain superfamily
Repeat	IPR000225	Armadillo
Repeat	IPR009223	Adenomatous polyposis coli protein repeat
Repeat	IPR009224	SAMP
Repeat	IPR041257	Adenomatous polyposis coli (APC) repeat