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Gene

apc2

ID
ZDB-GENE-090422-1
Name
APC regulator of WNT signaling pathway 2
Symbol
apc2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable beta-catenin binding activity; gamma-catenin binding activity; and microtubule binding activity. Predicted to be involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of microtubule depolymerization; and positive regulation of protein catabolic process. Predicted to act upstream of or within Wnt signaling pathway and negative regulation of Wnt signaling pathway. Predicted to be part of beta-catenin destruction complex and catenin complex. Predicted to colocalize with cytoplasmic microtubule. Human ortholog(s) of this gene implicated in Sotos syndrome 3 and complex cortical dysplasia with other brain malformations. Orthologous to human APC2 (APC regulator of WNT signaling pathway 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With apc2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Sotos syndrome 3 Alliance ?Sotos syndrome 3 617169
Cortical dysplasia, complex, with other brain malformations 10 618677
Associated With apc2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR009234 Adenomatous polyposis coli protein basic domain
Domain IPR032038 Adenomatous polyposis coli, N-terminal dimerisation domain
Family IPR026818 Adenomatous polyposis coli (APC) family
Family IPR026837 Adenomatous polyposis coli 2
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR026831 Adenomatous polyposis coli protein
Homologous_superfamily IPR036149 APC, N-terminal coiled-coil domain superfamily
Repeat IPR000225 Armadillo
Repeat IPR009223 Adenomatous polyposis coli protein repeat
Repeat IPR009224 SAMP
Repeat IPR041257 Adenomatous polyposis coli (APC) repeat
Domain Details Per Protein
Protein Length Adenomatous polyposis coli 2 Adenomatous polyposis coli (APC) family Adenomatous polyposis coli (APC) repeat Adenomatous polyposis coli, N-terminal dimerisation domain Adenomatous polyposis coli protein Adenomatous polyposis coli protein basic domain Adenomatous polyposis coli protein repeat APC, N-terminal coiled-coil domain superfamily Armadillo Armadillo-like helical Armadillo-type fold SAMP
UniProtKB:E7F064 2105
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations