ZFIN ID: ZDB-GENE-090417-2
Gene Name: GNAS complex locus
Gene Symbol: gnas    Nomenclature History

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Previous Name: Galpha s (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have G-protein beta/gamma-subunit complex binding activity; GTPase activity; and signaling receptor binding activity. Predicted to be involved in adenylate cyclase-activating dopamine receptor signaling pathway and sensory perception of chemical stimulus. Predicted to localize to heterotrimeric G-protein complex. Is expressed in brain; gill; head; heart; and olfactory epithelium. Human ortholog(s) of this gene implicated in several diseases, including ACTH-independent macronodular adrenal hyperplasia 1; McCune Albright syndrome; obesity; progressive osseous heteroplasia; and pseudohypoparathyroidism (multiple). Orthologous to human GNAS (GNAS complex locus).
Genome Resources: Alliance (1),  Gene:557353 (1),  Ensembl(GRCz11):ENSDARG00000043094 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9319 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gnas HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ACTH-independent macronodular adrenal hyperplasia 1 Alliance ACTH-independent macronodular adrenal hyperplasia 219080
    Albright's hereditary osteodystrophy Alliance Pseudohypoparathyroidism Ia 103580
    McCune Albright syndrome Alliance McCune-Albright syndrome, somatic, mosaic 174800
    progressive osseous heteroplasia Alliance Osseous heteroplasia, progressive 166350
    pseudohypoparathyroidism Alliance Pseudohypoparathyroidism Ic 612462
    pseudohypoparathyroidism type IB Alliance Pseudohypoparathyroidism Ib 603233
    pseudopseudohypoparathyroidism Alliance Pseudopseudohypoparathyroidism 612463
    Pituitary adenoma 3, multiple types, somatic 617686
    DISEASE ASSOCIATED WITH gnas VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component heterotrimeric G-protein complex (more)
    Molecular Function G-protein beta/gamma-subunit complex binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gnas-201 (1)    Ensembl 2255
    gnas-202 (1)    Ensembl 669
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gnas No data available
    MARKER RELATIONSHIPS
    gnas Contained in: [BAC] CH211-122I22
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_001335696 (1)
    Genomic GenBank:BX927257 (1) 133388 nt
    Select Tool
    Polypeptide UniProtKB:F1QJX7 (1) 379 aa
    Sequence Information (all 9)
    ORTHOLOGY for gnas ( Chr: 6 )
    CITATIONS (24)