ZFIN ID: ZDB-GENE-090410-5
Gene Name: cholinergic receptor, muscarinic 3b
Gene Symbol: chrm3b    Nomenclature History

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Previous Name: DrM3B (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; chemical synaptic transmission; and regulation of vascular smooth muscle contraction. Predicted to localize to dendrite; integral component of plasma membrane; and synapse. Is expressed in eye. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000071298 (1)
GENE EXPRESSION
All Expression Data: Fig. 2 from Nuckels et al., 2011
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa30967 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35376 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chrm3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    prune belly syndrome Alliance ?Prune belly syndrome 100100
    DISEASE ASSOCIATED WITH chrm3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component cell junction (more)
    Molecular Function G protein-coupled acetylcholine receptor activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chrm3b-201 (1)    Ensembl 1583
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrm3b No data available
    MARKER RELATIONSHIPS
    chrm3b Contained in: [BAC] CH73-367A6 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA GenBank:CO401033 (1) 865 nt
    Genomic GenBank:CU607101 (1) 119244 nt
    Select Tool
    Polypeptide UniProtKB:U3JAM0 (1) 494 aa
    ORTHOLOGY for chrm3b ( Chr: 12 )
    CITATIONS (17)