ZFIN ID: ZDB-GENE-090410-4
Gene Name: cholinergic receptor, muscarinic 3a
Gene Symbol: chrm3a    Nomenclature History

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Previous Name: DrM3A (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have G protein-coupled acetylcholine receptor activity and G protein-coupled serotonin receptor activity. Predicted to be involved in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway; chemical synaptic transmission; and regulation of vascular smooth muscle contraction. Predicted to localize to dendrite; integral component of plasma membrane; and synapse. Is expressed in eye. Human ortholog(s) of this gene implicated in bladder disease; chronic obstructive pulmonary disease; prune belly syndrome; and pulmonary fibrosis. Orthologous to human CHRM3 (cholinergic receptor muscarinic 3).
Genome Resources: Alliance (1),  Gene:571679 (1),  Ensembl(GRCz11):ENSDARG00000071091 (2)
GENE EXPRESSION
All Expression Data: Fig. 2 from Nuckels et al., 2011
Wild-type Stages, Structures: Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42905 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-chrm3a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH chrm3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    prune belly syndrome Alliance ?Prune belly syndrome 100100
    DISEASE ASSOCIATED WITH chrm3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component cell junction (more)
    Molecular Function G protein-coupled acetylcholine receptor activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA chrm3a-201 (1)    Ensembl 3277
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM chrm3a No data available
    MARKER RELATIONSHIPS
    chrm3a Contained in: [BAC] DKEY-97L21 (order this), DKEYP-90G2 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_695289 (1) 1788 nt
    Genomic GenBank:BX511254 (1) 185109 nt
    Select Tool
    Polypeptide UniProtKB:X1WHZ7 (1) 595 aa
    Sequence Information (all 11)
    ORTHOLOGY for chrm3a ( Chr: 17 )
    CITATIONS (21)