Gene

htr1ab

ID
ZDB-GENE-090409-2
Name
5-hydroxytryptamine (serotonin) receptor 1A b
Symbol
htr1ab Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Acts upstream of or within spinal cord motor neuron differentiation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in brain; pharynx; retina; and spinal cord. Human ortholog(s) of this gene implicated in anxiety disorder; mental depression; and panic disorder. Orthologous to human HTR1A (5-hydroxytryptamine receptor 1A).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Barreiro-Iglesias et al., 2015
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With htr1ab Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
vesicoureteral reflux Alliance Periodic fever, menstrual cycle dependent 614674
Associated With htr1ab Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR017452 GPCR, rhodopsin-like, 7TM
Family IPR000276 G protein-coupled receptor, rhodopsin-like
Family IPR000610 5-Hydroxytryptamine 1A receptor
Family IPR002231 5-hydroxytryptamine receptor family
Domain Details Per Protein
Protein Length 5-Hydroxytryptamine 1A receptor 5-hydroxytryptamine receptor family GPCR, rhodopsin-like, 7TM G protein-coupled receptor, rhodopsin-like
UniProtKB:C0ITL9 403
UniProtKB:E9QHE0 413
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations