Gene

sos2

ID
ZDB-GENE-090319-5
Name
son of sevenless homolog 2 (Drosophila)
Symbol
sos2 Nomenclature History
Previous Names
  • si:ch211-67f24.8
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Predicted to have DNA binding activity; guanyl-nucleotide exchange factor activity; and protein heterodimerization activity. Involved in pronephros development. Predicted to localize to nucleosome. Human ortholog(s) of this gene implicated in Noonan syndrome 9. Orthologous to human SOS2 (SOS Ras/Rho guanine nucleotide exchange factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Li et al., 2017
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Li et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With sos2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Noonan syndrome 9 Alliance Noonan syndrome 9 616559
Associated With sos2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019804 Ras guanine-nucleotide exchange factor, conserved site
Domain IPR000219 Dbl homology (DH) domain
Domain IPR000651 Ras-like guanine nucleotide exchange factor, N-terminal
Domain IPR001849 Pleckstrin homology domain
Domain IPR001895 Ras guanine-nucleotide exchange factors catalytic domain
Domain IPR007125 Histone H2A/H2B/H3
Family IPR008937 Ras-like guanine nucleotide exchange factor
Homologous_superfamily IPR009072 Histone-fold
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR023578 Ras guanine nucleotide exchange factor domain superfamily
Homologous_superfamily IPR035899 Dbl homology (DH) domain superfamily
Domain Details Per Protein
Protein Length Dbl homology (DH) domain Dbl homology (DH) domain superfamily Histone-fold Histone H2A/H2B/H3 PH-like domain superfamily Pleckstrin homology domain Ras guanine-nucleotide exchange factor, conserved site Ras guanine nucleotide exchange factor domain superfamily Ras guanine-nucleotide exchange factors catalytic domain Ras-like guanine nucleotide exchange factor Ras-like guanine nucleotide exchange factor, N-terminal
UniProtKB:F1R019 1341
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations