ZFIN ID: ZDB-GENE-090313-98
Gene Name: KIAA1109
Gene Symbol: kiaa1109    Nomenclature History

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Previous Name: si:ch211-233a24.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to be involved in endocytic recycling; phagocytosis; and synaptic vesicle endocytosis. Predicted to localize to integral component of membrane. Used to study Alkuraya-Kucinskas syndrome. Human ortholog(s) of this gene implicated in Alkuraya-Kucinskas syndrome. Orthologous to human KIAA1109 (KIAA1109).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000062330 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027382Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2675 Point Mutation Unknown Premature Stop ENU
    sa2712 Point Mutation Unknown Premature Stop ENU
    sa9351 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13491 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13514 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13875 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15043 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17693 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24928 Point Mutation Unknown Premature Stop ENU
    sa35438 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35439 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35440 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35441 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42156 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42157 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zf3026 Small Deletion Unknown Unknown CRISPR
    zf3027 Indel Unknown Unknown CRISPR
    zf3028 Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kiaa1109 1
    CRISPR2-kiaa1109 1
    CRISPR3-kiaa1109 1
    MO1-kiaa1109 N/A 1
    MO2-kiaa1109 N/A 1
    PHENOTYPE
    Data: Fig. 5 from Gueneau et al., 2017
    Observed in:
    DISEASE ASSOCIATED WITH kiaa1109 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alkuraya-Kucinskas syndrome Alliance Alkuraya-Kucinskas syndrome 617822
    DISEASE ASSOCIATED WITH kiaa1109 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Alkuraya-Kucinskas syndrome TU + MO2-kiaa1109 standard conditions Gueneau et al., 2017
    TU + MO1-kiaa1109 standard conditions Gueneau et al., 2017
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process endocytic recycling (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA si:ch211-233a24.2-201 (1)    Ensembl 15591
    ncRNA si:ch211-233a24.2-002 (1)    Ensembl 522
    si:ch211-233a24.2-003 (1)    Ensembl 739
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kiaa1109 No data available
    MARKER RELATIONSHIPS
    kiaa1109 Contained in: [BAC] CH211-129A13 (1), CH211-233A24 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:CR555301 (1) 168518 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IES7 (1) 4923 aa
    Sequence Information (all 8)
    ORTHOLOGY for kiaa1109 ( Chr: 13 )
    CITATIONS (17)