Gene

apbb2b

ID

ZDB-GENE-090313-73

Name

amyloid beta (A4) precursor protein-binding, family B, member 2b

Symbol

apbb2b Nomenclature History

Previous Names

apbb2
si:ch211-201g8.2

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have amyloid-beta binding activity and transcription factor binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to localize to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease and cognitive disorder. Orthologous to human APBB2 (amyloid beta precursor protein binding family B member 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Anderson et al., 2020

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With apbb2b Human Ortholog

No data available

Associated With apbb2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR001202	WW domain
Domain	IPR006020	PTB/PI domain
Family	IPR039576	Amyloid beta precursor protein binding family B member 1/2/3
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR036020	WW domain superfamily

Domain Details Per Protein

Protein	Length	Amyloid beta precursor protein binding family B member 1/2/3	PH-like domain superfamily	PTB/PI domain	WW domain	WW domain superfamily
UniProtKB:A0A8M3AZH4 InterPro	889
UniProtKB:A0A8M9PIS6 InterPro	890
UniProtKB:A0A8N7TDH9 InterPro	890
UniProtKB:A0A8M2BFP7 InterPro	211
UniProtKB:A0A8M9PKH7 InterPro	874
UniProtKB:A0A8M2BFP9 InterPro	892
UniProtKB:A0A8M3B8B5 InterPro	590
UniProtKB:A0A8M6YY48 InterPro	891

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	apbb2b-201 (1) Ensembl	Havana	3326 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	apbb2b-203 (1) Ensembl	Havana	479 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	apbb2b-002 (1) Ensembl	Havana	527 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations