ZFIN ID: ZDB-GENE-090313-66
Gene Name: cytochrome c oxidase assembly factor 8
Gene Symbol: coa8    Nomenclature History

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Previous Names: apopt1, si:ch211-194h13.2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to be involved in intrinsic apoptotic signaling pathway; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; and positive regulation of release of cytochrome c from mitochondria. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in cytochrome-c oxidase deficiency disease. Orthologous to human COA8 (cytochrome c oxidase assembly factor 8).
Genome Resources: Alliance (1),  Gene:798687 (1),  Ensembl(GRCz11):ENSDARG00000092473 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a213 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-coa8 1
CRISPR2-coa8 1
CRISPR3-coa8 1
CRISPR4-coa8 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH coa8 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
cytochrome-c oxidase deficiency disease Alliance Mitochondrial complex IV deficiency 220110
DISEASE ASSOCIATED WITH coa8 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process intrinsic apoptotic signaling pathway (more)
Cellular Component mitochondrion (more)
GO Terms (all 2)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR018796 Cytochrome c oxidase assembly factor 8
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA apopt1-201 (1)    Ensembl 1249
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM coa8 No data available
MARKER RELATIONSHIPS
coa8 Contained in: [BAC] CH211-194H13 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001145619 (1)
Genomic GenBank:BX569782 (1) 115194 nt
Select Tool
Polypeptide UniProtKB:B8A5M9 (1) 205 aa
Sequence Information (all 5)
ORTHOLOGY for coa8 ( Chr: 13 )
CITATIONS (14)