Gene

prss12

ID
ZDB-GENE-090313-45
Name
serine protease 12
Symbol
prss12 Nomenclature History
Previous Names
  • si:ch211-152j23.2
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to have serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to localize to several cellular components, including dendrite; synaptic cleft; and terminal bouton. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With prss12 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal recessive non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 1 249500
Associated With prss12 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR033116 Serine proteases, trypsin family, serine active site
Conserved_site IPR018056 Kringle, conserved site
Domain IPR000001 Kringle
Domain IPR001190 SRCR domain
Domain IPR001254 Serine proteases, trypsin domain
Domain IPR017448 SRCR-like domain
Family IPR001314 Peptidase S1A, chymotrypsin family
Homologous_superfamily IPR009003 Peptidase S1, PA clan
Homologous_superfamily IPR013806 Kringle-like fold
Homologous_superfamily IPR036772 SRCR-like domain superfamily
Homologous_superfamily IPR038178 Kringle superfamily
Homologous_superfamily IPR043504 Peptidase S1, PA clan, chymotrypsin-like fold
Domain Details Per Protein
Protein Length Kringle Kringle, conserved site Kringle-like fold Kringle superfamily Peptidase S1A, chymotrypsin family Peptidase S1, PA clan Peptidase S1, PA clan, chymotrypsin-like fold Serine proteases, trypsin domain Serine proteases, trypsin family, serine active site SRCR domain SRCR-like domain SRCR-like domain superfamily
UniProtKB:F1QM24 816
UniProtKB:F1QC16 667
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations