ZFIN ID: ZDB-GENE-090313-45
Gene Name: serine protease 12
Gene Symbol: prss12    Nomenclature History

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Previous Name: si:ch211-152j23.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to localize to several cellular components, including dendrite; synaptic cleft; and terminal bouton. Human ortholog(s) of this gene implicated in autosomal recessive non-syndromic intellectual disability and intellectual disability. Orthologous to human PRSS12 (serine protease 12).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000061830 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021031Tg Transgenic Insertion Unknown Unknown DNA
sa14034 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko389a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-prss12 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH prss12 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive non-syndromic intellectual disability Alliance Mental retardation, autosomal recessive 1 249500
    DISEASE ASSOCIATED WITH prss12 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Cellular Component membrane (more)
    Molecular Function scavenger receptor activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prss12-202 (1)    Ensembl 5200
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prss12 No data available
    MARKER RELATIONSHIPS
    prss12 Contained in: [BAC] CH211-152J23 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:BX511095 (1) 152368 nt
    Select Tool
    Polypeptide UniProtKB:F1QM24 (1) 816 aa
    Sequence Information (all 3)
    ORTHOLOGY for prss12 ( Chr: 1 )
    CITATIONS (18)