ZFIN ID: ZDB-GENE-090313-378
Gene Name: heparanase 2
Gene Symbol: hpse2    Nomenclature History

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Previous Name: si:dkeyp-22h2.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have hydrolase activity, acting on glycosyl bonds. Predicted to localize to extracellular matrix. Is expressed in liver. Human ortholog(s) of this gene implicated in urofacial syndrome. Orthologous to human HPSE2 (heparanase 2 (inactive)).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000078163 (1)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la018623Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH hpse2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    urofacial syndrome Alliance Urofacial syndrome 1 236730
    DISEASE ASSOCIATED WITH hpse2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component membrane (more)
    Molecular Function hydrolase activity, acting on glycosyl bonds (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hpse2-202 (1)    Ensembl 456
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hpse2 No data available
    MARKER RELATIONSHIPS
    hpse2 Contained in: [BAC] DKEY-227C19 (1) (order this), DKEYP-22H2 (1), DKEYP-34H12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:CR384100 (1) 172918 nt
    Select Tool
    Polypeptide UniProtKB:F1QMQ5 (1) 560 aa
    Sequence Information (all 5)
    ORTHOLOGY for hpse2 ( Chr: 13 )
    CITATIONS (18)