ZFIN ID: ZDB-GENE-090313-268
Gene Name: lebercilin LCA5
Gene Symbol: lca5    Nomenclature History

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Previous Name: si:dkey-241o6.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to be involved in intraciliary transport. Predicted to localize to the axoneme. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 5. Orthologous to human LCA5 (lebercilin LCA5).
Genome Resources: Alliance (1),  Gene:100151323 (1),  Ensembl(GRCz11):ENSDARG00000076153 (1)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hzu7 Small Deletion Exon 2 Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • sa1415 Point Mutation Unknown Missense, Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa6746 Point Mutation Unknown Premature Stop ENU
    sa9927 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10874 Point Mutation Unknown Missense, Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11604 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37754 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37755 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lca5 1
    CRISPR2-lca5
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH lca5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Leber congenital amaurosis 5 Alliance Leber congenital amaurosis 5 604537
    DISEASE ASSOCIATED WITH lca5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process intraciliary transport (more)
    Cellular Component axoneme (more)
    GO Terms (all 2)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR026188 Lebercilin-like
    Family IPR026684 Lebercilin
    Domain IPR028933 Lebercilin domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lca5-202 (1)    Ensembl 2690
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lca5 No data available
    MARKER RELATIONSHIPS
    lca5 Contained in: [BAC] DKEY-241O6 (1) (order this), DKEYP-79F12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009297006 (1)
    Genomic RefSeq:NW_018395159 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:E9QG33 (1) 754 aa
    Sequence Information (all 43)
    ORTHOLOGY for lca5 ( Chr: 23 )
    CITATIONS (17)