ZFIN ID: ZDB-GENE-090313-235
Gene Name: endothelin 3b
Gene Symbol: edn3b    Nomenclature History

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Previous Names: edn3, si:dkey-211h10.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Involved in melanocyte differentiation and pigment cell development. Predicted to localize to extracellular region. Is expressed in epidermis. Human ortholog(s) of this gene implicated in Hirschsprung's disease; Waardenburg syndrome type 4B; Waardenburg's syndrome; and congenital central hypoventilation syndrome. Orthologous to human EDN3 (endothelin 3).
Genome Resources: Alliance (1),  Gene:100148183 (1), 
GENE EXPRESSION
All Expression Data: Fig. 5 from Krauss et al., 2014
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Hatching:Long-pec (48.0h-60.0h)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1283 Indel Unknown Frameshift, Premature Stop CRISPR
mk203 Unknown Unknown Unknown CRISPR
sa15826 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vp30rc1 Indel Unknown Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-edn3b 2
    CRISPR2-edn3b 1
    MO1-edn3b N/A 1
    MO2-edn3b N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH edn3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome, congenital 209880
    Waardenburg syndrome type 4B Alliance Waardenburg syndrome, type 4B 613265
    {Hirschsprung disease, susceptibility to, 4} 613712
    DISEASE ASSOCIATED WITH edn3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process melanocyte differentiation (more)
    Cellular Component extracellular region (more)
    Molecular Function endothelin B receptor binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA edn3b-201 (1)    Ensembl 1267
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM edn3b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(hsp70l:edn3b-2a-nls-venus) hsp70l 2Aedn3bNLSVenus Danio rerio 1 1
    MARKER RELATIONSHIPS
    edn3b Contained in: [BAC] DKEY-211H10 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001311213 (1)
    Genomic GenBank:AL929345 (1) 222615 nt Blast at MegaBLAST
    Polypeptide UniProtKB:E9QFS0 (1) 153 aa
    Sequence Information (all 7)
    ORTHOLOGY for edn3b ( Chr: 23 )
    CITATIONS (16)