Gene

slc4a11

ID

ZDB-GENE-090313-183

Name

solute carrier family 4 member 11

Symbol

slc4a11 Nomenclature History

Previous Names

si:dkey-12j14.4

Type

protein_coding_gene

Location

Chr: 13 Mapping Details/Browsers

Description

Predicted to enable transmembrane transporter activity. Predicted to be involved in monoatomic ion homeostasis and transmembrane transport. Predicted to act upstream of or within monoatomic anion transport. Predicted to be located in membrane. Predicted to be active in basolateral plasma membrane. Is expressed in several structures, including eye; gill; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

1 figure from Lee et al., 2011

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With slc4a11 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
congenital hereditary endothelial dystrophy of cornea	Alliance	Corneal endothelial dystrophy, autosomal recessive	217700
corneal dystrophy-perceptive deafness syndrome	Alliance	Corneal endothelial dystrophy and perceptive deafness	217400
Fuchs' endothelial dystrophy	Alliance	Corneal dystrophy, Fuchs endothelial, 4	613268

Associated With slc4a11 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011531	Bicarbonate transporter-like, transmembrane domain
Family	IPR003020	Bicarbonate transporter, eukaryotic
Homologous_superfamily	IPR016152	Phosphotransferase/anion transporter

Domain Details Per Protein

Protein	Length	Bicarbonate transporter, eukaryotic	Bicarbonate transporter-like, transmembrane domain	Phosphotransferase/anion transporter
UniProtKB:A0A8M1NRH1 InterPro	846
UniProtKB:A0A8M2B2N8 InterPro	877

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	slc4a11-201 (1) Ensembl	Ensembl	2,798 nt	Select Tool ZFIN BLAST
mRNA	slc4a11-202 (1) Ensembl	Ensembl	2,349 nt	Select Tool ZFIN BLAST
mRNA	slc4a11-203 (1) Ensembl	Ensembl	2,457 nt	Select Tool ZFIN BLAST

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations