ZFIN ID: ZDB-GENE-090313-183
Gene Name: solute carrier family 4 member 11
Gene Symbol: slc4a11    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Name: si:dkey-12j14.4

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have inorganic anion exchanger activity. Predicted to be involved in regulation of intracellular pH. Predicted to localize to integral component of membrane. Is expressed in several structures, including eye; gill; heart; muscle; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy; congenital hereditary endothelial dystrophy of cornea; and corneal dystrophy-perceptive deafness syndrome. Orthologous to human SLC4A11 (solute carrier family 4 member 11).
Genome Resources: Alliance (1),  Gene:559346 (1),  Ensembl(GRCz11):ENSDARG00000075532 (1)
GENE EXPRESSION
All Expression Data: Fig. 4 from Lee et al., 2011
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027385Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35444 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38927 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slc4a11 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital hereditary endothelial dystrophy of cornea Alliance Corneal endothelial dystrophy, autosomal recessive 217700
    corneal dystrophy-perceptive deafness syndrome Alliance Corneal endothelial dystrophy and perceptive deafness 217400
    Fuchs' endothelial dystrophy Alliance Corneal dystrophy, Fuchs endothelial, 4 613268
    DISEASE ASSOCIATED WITH slc4a11 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process anion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function inorganic anion exchanger activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc4a11-201 (1)    Ensembl 2798
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc4a11 No data available
    MARKER RELATIONSHIPS
    slc4a11 Contained in: [BAC] CH211-194C3 (1), DKEY-12J14 (1) (order this), DKEY-170I22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001159828 (1) 2541 nt
    Genomic GenBank:CR788322 (1) 234400 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F6NGR0 (1) 846 aa
    Sequence Information (all 12)
    ORTHOLOGY for slc4a11 ( Chr: 13 )
    CITATIONS (18)