Gene

socs1b

ID
ZDB-GENE-090313-141
Name
suppressor of cytokine signaling 1b
Symbol
socs1b Nomenclature History
Previous Names
  • si:ch73-191k20.2 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable 1-phosphatidylinositol-3-kinase regulator activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within intracellular signal transduction; regulation of growth; and regulation of signal transduction. Predicted to be located in cytoplasm. Predicted to be part of phosphatidylinositol 3-kinase complex. Is expressed in head kidney. Human ortholog(s) of this gene implicated in acute myeloid leukemia; gastrointestinal system cancer (multiple); reproductive organ cancer (multiple); and urinary bladder cancer. Orthologous to human SOCS1 (suppressor of cytokine signaling 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from López-Muñoz et al., 2015
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Lawir et al., 2017
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With socs1b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Autoinflammatory syndrome, familial, with or without immunodeficiency 619375
Associated With socs1b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000980 SH2 domain
Domain IPR001496 SOCS box domain
Domain IPR035861 SOCS1, SH2 domain
Family IPR028411 Suppressor of cytokine signalling 1
Homologous_superfamily IPR036036 SOCS box-like domain superfamily
Homologous_superfamily IPR036860 SH2 domain superfamily
Domain Details Per Protein
Protein Length SH2 domain SH2 domain superfamily SOCS1, SH2 domain SOCS box domain SOCS box-like domain superfamily Suppressor of cytokine signalling 1
UniProtKB:E7FDH8 193
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations