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ZIRC
ZFIN ID: ZDB-GENE-090313-116
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Gene Name: apelin receptor early endogenous ligand
Gene Symbol: apela    Nomenclature History

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Previous Names: ela, tdl, elabela (1), ende, linc_tmem192 (1), si:ch211-42i9.4, toddler

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Exhibits apelin receptor binding activity and hormone activity. Involved in several processes, including apelin receptor signaling pathway; circulatory system development; and gastrulation. Localizes to the extracellular space. Is expressed in hypoblast; mesoderm; neural rod; neural tube; and notochord. Orthologous to human APELA (apelin receptor early endogenous ligand).
Genome Resources: Alliance (1),  Gene:100536023 (1),  Ensembl(GRCz11):ENSDARG00000094729 (1)
GENE EXPRESSION
All Expression Data: 7 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a141 Small Deletion Unknown Frameshift TALEN
a142 Indel Unknown Frameshift TALEN
la011777Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • zf438 Small Deletion Unknown Unknown ZINC_FINGER_NUCLEASE
    zf439 Small Deletion Unknown Frameshift ZINC_FINGER_NUCLEASE
    zf440 Small Deletion Unknown Frameshift ZINC_FINGER_NUCLEASE
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-apela
    		1
    CRISPR2-apela
    		1
    CRISPR3-apela
    		1
    CRISPR4-apela
    		1
    MO1-apela N/A 1
    TALEN1-apela 1
    PHENOTYPE
    Data: 22 figures from 4 publications
    Observed in:
    DISEASE ASSOCIATED WITH apela HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH apela VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process apelin receptor signaling pathway (more)
    Cellular Component extracellular space (more)
    Molecular Function apelin receptor binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA apela-201 (1)    Ensembl 748
    Select Tool
    apela-202 (1)    Ensembl 867
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM apela
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:apela,myl7:EGFP) hsp70l,  myl7 apela,  EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    apela Contained in: [BAC] CH211-42I9 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001297547 (1)
    Select Tool
    Genomic GenBank:BX323590 (1) 178876 bp
    Select Tool
    Polypeptide UniProtKB:A0A0R4IR01 (1) 49 aa
    Select Tool
    Sequence Clusters UniGene:81857 (1)
    Sequence Information (all 9)
    ORTHOLOGY for apela ( Chr: 1 )
    CITATIONS (30)