Gene

tet2

ID
ZDB-GENE-090312-98
Name
tet methylcytosine dioxygenase 2
Symbol
tet2 Nomenclature History
Previous Names
  • tet2l (1)
  • im:7136741
  • si:ch211-216c6.1
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Exhibits methylcytosine dioxygenase activity. Involved in several processes, including cell surface receptor signaling pathway; endothelial to hematopoietic transition; and primitive erythrocyte differentiation. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; eye; hematopoietic system; liver; and pleuroperitoneal region. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia; chronic myelomonocytic leukemia; myelodysplastic syndrome; and myeloproliferative neoplasm. Orthologous to human TET2 (tet methylcytosine dioxygenase 2).
Genome Resources
Note
None
Expression
All Expression Data
12 figures from 10 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tet2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
myelodysplastic syndrome Alliance Myelodysplastic syndrome, somatic 614286
Immunodeficiency 75 619126
Associated With tet2 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR024779 2OGFeDO, oxygenase domain
Family IPR040175 Methylcytosine dioxygenase TET1/2/3
Domain Details Per Protein
Protein Length 2OGFeDO, oxygenase domain Methylcytosine dioxygenase TET1/2/3
UniProtKB:A0A286YAQ6 1697
UniProtKB:E7F958 1715
UniProtKB:A0A2R8RZ82 1712
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations