ZFIN ID: ZDB-GENE-090312-50
Gene Name: ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Gene Symbol: arfgef2    Nomenclature History

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Previous Name: si:dkey-192i18.4

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of ARF protein signal transduction. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000074702 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa9158 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14736 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-arfgef2 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH arfgef2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    periventricular nodular heterotopia Alliance Periventricular heterotopia with microcephaly 608097
    DISEASE ASSOCIATED WITH arfgef2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of ARF protein signal transduction (more)
    Molecular Function ARF guanyl-nucleotide exchange factor activity (more)
    GO Terms (all 3)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA arfgef2-202 (1)    Ensembl 5909
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM arfgef2 No data available
    MARKER RELATIONSHIPS
    arfgef2 Contained in: [BAC] DKEY-192I18 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:CR788311 (1) 147664 nt
    Select Tool
    Polypeptide UniProtKB:E7FCG1 (1) 1846 aa
    Sequence Information (all 3)
    ORTHOLOGY for arfgef2 ( Chr: 23 )
    CITATIONS (13)