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Gene

arfgef2

ID
ZDB-GENE-090312-50
Name
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
Symbol
arfgef2 Nomenclature History
Previous Names
  • si:dkey-192i18.4
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to enable guanyl-nucleotide exchange factor activity. Acts upstream of or within with a positive effect on angioblast cell migration and cell migration involved in sprouting angiogenesis. Predicted to be located in Golgi apparatus and perinuclear region of cytoplasm. Is expressed in brain. Human ortholog(s) of this gene implicated in periventricular nodular heterotopia. Orthologous to human ARFGEF2 (ADP ribosylation factor guanine nucleotide exchange factor 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Lu et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Lu et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With arfgef2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
periventricular nodular heterotopia Alliance Periventricular heterotopia with microcephaly 608097
Associated With arfgef2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000904 Sec7 domain
Domain IPR015403 Sec7, C-terminal
Domain IPR032629 Mon2, dimerisation and cyclophilin-binding domain
Domain IPR032691 Guanine nucleotide exchange factor, N-terminal
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR023394 Sec7, C-terminal domain superfamily
Homologous_superfamily IPR035999 Sec7 domain superfamily
Domain Details Per Protein
Protein Length Armadillo-type fold Guanine nucleotide exchange factor, N-terminal Mon2, dimerisation and cyclophilin-binding domain Sec7, C-terminal Sec7, C-terminal domain superfamily Sec7 domain Sec7 domain superfamily
UniProtKB:E9QF76 1832
UniProtKB:E7FCG1 1846
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations