Gene

dvl1a

ID
ZDB-GENE-090312-40
Name
dishevelled segment polarity protein 1a
Symbol
dvl1a Nomenclature History
Previous Names
  • si:dkey-223i19.4 (1)
Type
protein_coding_gene
Location
Chr: 23 Mapping Details/Browsers
Description
Predicted to have frizzled binding activity. Predicted to be involved in canonical Wnt signaling pathway and planar cell polarity pathway involved in neural tube closure. Predicted to localize to cytosol. Human ortholog(s) of this gene implicated in DiGeorge syndrome and autosomal dominant Robinow syndrome 2. Orthologous to human DVL1 (dishevelled segment polarity protein 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Costa et al., 2020
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dvl1a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autosomal dominant Robinow syndrome 2 Alliance Robinow syndrome, autosomal dominant 2 616331
Associated With dvl1a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000591 DEP domain
Domain IPR001478 PDZ domain
Domain IPR003351 Dishevelled protein domain
Domain IPR024580 Dishevelled C-terminal
Family IPR008339 Dishevelled family
Family IPR008340 Dishevelled-1
Family IPR015506 Dishevelled-related protein
Homologous_superfamily IPR036034 PDZ superfamily
Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length DEP domain Dishevelled-1 Dishevelled C-terminal Dishevelled family Dishevelled protein domain Dishevelled-related protein PDZ domain PDZ superfamily Winged helix DNA-binding domain superfamily Winged helix-like DNA-binding domain superfamily
UniProtKB:F1QBS2
UniProtKB:E7FAJ8
UniProtKB:A0A2R8QMS8 475
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations