ZFIN is now using GRCz12tu for Genomic Data
Gene
npnta
- ID
- ZDB-GENE-090312-201
- Name
- nephronectin a
- Symbol
- npnta Nomenclature History
- Previous Names
-
- npnt
- si:ch211-202n8.2
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Genome Assembly
- GRCz12tu
- Annotation Status
- Current
- Description
- Predicted to enable calcium ion binding activity. Acts upstream of or within atrioventricular valve development and heart trabecula formation. Predicted to be located in membrane. Is expressed in several structures, including digestive system; endoderm; head; heart; and tail bud. Used to study membranous glomerulonephritis and proteinuria. Orthologous to human NPNT (nephronectin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 6 figures from 4 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 15 figures from 4 publications
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| proteinuria | WT + MO2-npnta | standard conditions | Müller-Deile et al., 2017 |
| membranous glomerulonephritis | WT + MO2-npnta | standard conditions | Müller-Deile et al., 2017 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR018097 | EGF-like calcium-binding, conserved site |
| Domain | IPR000742 | EGF-like domain |
| Domain | IPR000998 | MAM domain |
| Domain | IPR001881 | EGF-like calcium-binding domain |
| Domain | IPR024731 | EGF domain |
| Domain | IPR049883 | NOTCH1 EGF-like calcium-binding domain |
| Family | IPR052235 | Nephronectin domain-containing protein |
| Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
| Homologous_superfamily | IPR013320 | Concanavalin A-like lectin/glucanase domain superfamily |
| PTM | IPR000152 | EGF-type aspartate/asparagine hydroxylation site |
Domain Details Per Protein
| Protein | Additional Resources | Length | Concanavalin A-like lectin/glucanase domain superfamily | EGF domain | EGF-like calcium-binding, conserved site | EGF-like calcium-binding domain | EGF-like domain | EGF-type aspartate/asparagine hydroxylation site | Growth factor receptor cysteine-rich domain superfamily | MAM domain | Nephronectin domain-containing protein | NOTCH1 EGF-like calcium-binding domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M2B6Z0 | InterPro | 619 | ||||||||||
| UniProtKB:A0A8M3AVI7 | InterPro | 588 | ||||||||||
| UniProtKB:B8A5G4 | InterPro | 605 | ||||||||||
| UniProtKB:A0A8M3B3H9 | InterPro | 636 |
- Genome Browsers
Interactions and Pathways
No data available
Plasmids
No data available
- Genome Browsers