ZFIN ID: ZDB-GENE-090311-8
Gene Name: oxoglutarate (alpha-ketoglutarate) dehydrogenase b (lipoamide)
Gene Symbol: ogdhb    Nomenclature History

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Previous Name: si:ch211-229p19.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have oxoglutarate dehydrogenase (succinyl-transferring) activity. Involved in heart contraction. Predicted to localize to the mitochondrion and oxoglutarate dehydrogenase complex. Orthologous to human OGDH (oxoglutarate dehydrogenase).
Genome Resources: Alliance (1),  Gene:797715 (1),  Ensembl(GRCz11):ENSDARG00000103428 (1)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la027200Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11227 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34993 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ogdhb N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ogdhb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Alpha-ketoglutarate dehydrogenase deficiency 203740
    DISEASE ASSOCIATED WITH ogdhb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart contraction (more)
    Cellular Component mitochondrion (more)
    Molecular Function oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001017 Dehydrogenase, E1 component
    Domain IPR005475 Transketolase-like, pyrimidine-binding domain
    Family IPR011603 2-oxoglutarate dehydrogenase E1 component
    Homologous_superfamily IPR029061 Thiamin diphosphate-binding fold
    Domain IPR031717 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal
    Domain IPR032106 2-oxoglutarate dehydrogenase E1 component, N-terminal domain
    Homologous_superfamily IPR042179 Multifunctional 2-oxoglutarate metabolism enzyme, C-terminal domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ogdhb-202 (1)    Ensembl 6065
    ncRNA ogdhb-002 (1) 414
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ogdhb No data available
    MARKER RELATIONSHIPS
    ogdhb Contained in: [BAC] CH211-229P19 (1), DKEY-259K14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001338145 (1) 3493 bp
    Genomic GenBank:CT956056 (1) 151889 bp
    Select Tool
    Polypeptide UniProtKB:E7EZ05 (1) 1023 aa
    Sequence Information (all 16)
    ORTHOLOGY for ogdhb ( Chr: 10 )
    CITATIONS (19)