ZFIN ID: ZDB-GENE-090311-47
Gene Name: arachidonate 5-lipoxygenase a
Gene Symbol: alox5a    Nomenclature History

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Previous Names: ALOX2 (1), alox5, LOX2 (1), si:dkey-194n13.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits arachidonate 5-lipoxygenase activity; arachidonic acid monooxygenase activity; and leukotriene-C4 synthase activity. Involved in arachidonic acid metabolic process. Predicted to localize to cytosol; nuclear envelope; and plasma membrane. Is expressed in pronephric duct. Human ortholog(s) of this gene implicated in arteriosclerosis; asthma; pancreatic cancer; pulmonary hypertension; and pulmonary tuberculosis. Orthologous to human ALOX5 (arachidonate 5-lipoxygenase).
Genome Resources: Alliance (1),  Gene:567204 (1),  Ensembl(GRCz11):ENSDARG00000057273 (1)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
PHENOTYPE No data available
DISEASE ASSOCIATED WITH alox5a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
asthma Alliance {Asthma, diminished response to antileukotriene treatment in} 600807
{Atherosclerosis, susceptibility to}
DISEASE ASSOCIATED WITH alox5a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process arachidonic acid metabolic process (more)
Cellular Component nuclear envelope (more)
Molecular Function arachidonate 5-lipoxygenase activity (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA alox5a-201 (1)    Ensembl 2039
ncRNA alox5a-002 (1)    Ensembl 489
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM alox5a No data available
MARKER RELATIONSHIPS
alox5a Contained in: [BAC] DKEY-194N13 (1) (order this), DKEY-228D14 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001256747 (1) 2036 nt
Genomic GenBank:BX927098 (1) 229413 nt Blast at MegaBLAST
Polypeptide UniProtKB:A0A2R8RVT0 (1) 674 aa
Sequence Information (all 8)
ORTHOLOGY for alox5a ( Chr: 13 )
CITATIONS (27)