ZFIN ID: ZDB-GENE-090311-43
Gene Name: eph receptor A6
Gene Symbol: epha6    Nomenclature History

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Previous Name: si:ch211-247c17.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to the integral component of plasma membrane; neuron projection; and receptor complex. Orthologous to human EPHA6 (EPH receptor A6).
Genome Resources: Alliance (1),  Gene:100005538 (1),  Ensembl(GRCz11):ENSDARG00000022971 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la021135Tg Transgenic Insertion Unknown Unknown DNA
sa13485 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38274 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39638 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39639 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko635a Small Deletion Unknown Unknown CRISPR
  • China Zebrafish Resource Center (CZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-epha6 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH epha6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH epha6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001090 Ephrin receptor ligand binding domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Domain IPR001660 Sterile alpha motif domain
    Domain IPR003961 Fibronectin type III
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR016257 Ephrin receptor type-A /type-B
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Domain IPR027936 Ephrin receptor, transmembrane domain
    Domain IPR034280 Ephrin type-A receptor 6, ligand binding domain
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA epha6-202 (1)    Ensembl 638
    epha6-203 (1)    Ensembl 5632
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM epha6 No data available
    MARKER RELATIONSHIPS
    epha6 Contained in: [BAC] CH211-176A2 (1), CH211-247C17 (1), DKEY-24D16 (1) (order this), DKEY-24H22 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005159930 (1) 4761 bp
    Genomic GenBank:BX901972 (1) 212798 bp Blast at MegaBLAST
    Polypeptide UniProtKB:F6P3V1 (1) 1001 aa
    Sequence Information (all 23)
    ORTHOLOGY for epha6 ( Chr: 1 )
    CITATIONS (22)