Gene

cnnm2b

ID
ZDB-GENE-090311-26
Name
cyclin and CBS domain divalent metal cation transport mediator 2b
Symbol
cnnm2b Nomenclature History
Previous Names
  • cnnm2
  • si:ch211-176l1.6 (1)
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Involved in brain development and magnesium ion homeostasis. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; heart; opercular flap; pleuroperitoneal region; and scale. Used to study schizophrenia. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 4 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With cnnm2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Hypomagnesemia 6, renal 613882
Hypomagnesemia, seizures, and impaired intellectual development 1 616418
Associated With cnnm2b Via Experimental Models
Human Disease Fish Conditions Citations
schizophrenia cnnm2ba258/a258 standard conditions Thyme et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000644 CBS domain
Domain IPR002550 CNNM, transmembrane domain
Domain IPR044751 Ion transporter-like, CBS domain
Family IPR045095 Ancient conserved domain protein family
Homologous_superfamily IPR018490 Cyclic nucleotide-binding domain superfamily
Homologous_superfamily IPR046342 CBS domain superfamily
Domain Details Per Protein
Protein Length Ancient conserved domain protein family CBS domain CBS domain superfamily CNNM, transmembrane domain Cyclic nucleotide-binding domain superfamily Ion transporter-like, CBS domain
UniProtKB:A0A8M3AJ29 830
UniProtKB:F1QIW8 807
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA cnnm2b-201 (1) Havana 4352 nt
mRNA cnnm2b-202 (1) Ensembl 2351 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations