ZFIN ID: ZDB-GENE-090311-26
Gene Name: cyclin and CBS domain divalent metal cation transport mediator 2b
Gene Symbol: cnnm2b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: cnnm2, si:ch211-176l1.6 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Involved in brain development and magnesium ion homeostasis. Predicted to localize to integral component of membrane. Is expressed in several structures, including digestive system; heart; opercular flap; pleuroperitoneal region; and scale. Used to study schizophrenia. Human ortholog(s) of this gene implicated in renal hypomagnesemia 6. Orthologous to human CNNM2 (cyclin and CBS domain divalent metal cation transport mediator 2).
Genome Resources: Alliance (1),  Gene:565702 (1),  Ensembl(GRCz11):ENSDARG00000078733 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 2 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a258 Small Deletion Unknown Unknown CRISPR
sa1438 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-cnnm2b 1
CRISPR2-cnnm2b 1
CRISPR3-cnnm2b 1
CRISPR4-cnnm2b 1
MO1-cnnm2b N/A 1
DISEASE ASSOCIATED WITH cnnm2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
renal hypomagnesemia 6 Alliance Hypomagnesemia 6, renal 613882
Hypomagnesemia, seizures, and mental retardation 616418
DISEASE ASSOCIATED WITH cnnm2b VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
schizophrenia cnnm2ba258/a258 standard conditions Thyme et al., 2019
GENE ONTOLOGY
Ontology GO Term
Biological Process brain development (more)
Cellular Component integral component of membrane (more)
Molecular Function magnesium ion transmembrane transporter activity (more)
GO Terms (all 7)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA cnnm2b-201 (1)    Ensembl 4352
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cnnm2b No data available
MARKER RELATIONSHIPS
cnnm2b Contained in: [BAC] CH211-157N19 (1), CH211-176L1 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_001922770 (1)
Genomic GenBank:CR812482 (1) 179573 nt
Select Tool
Polypeptide UniProtKB:F1QIW8 (1) 807 aa
Sequence Information (all 10)
ORTHOLOGY for cnnm2b ( Chr: 1 )
CITATIONS (21)