Gene

hecw2a

ID
ZDB-GENE-090311-22
Name
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2a
Symbol
hecw2a Nomenclature History
Previous Names
  • hecw2
  • nedl2a (1)
  • si:dkey-191g15.6
Type
protein_coding_gene
Location
Chr: 9 Mapping Details/Browsers
Description
Predicted to have ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of sodium ion transmembrane transporter activity; and regulation of dendrite morphogenesis. Predicted to localize to cytoplasm. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).
Genome Resources
Note
None
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With hecw2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Neurodevelopmental disorder with hypotonia, seizures, and absent language 617268
Associated With hecw2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000008 C2 domain
Domain IPR000569 HECT domain
Domain IPR001202 WW domain
Domain IPR032348 E3 ubiquitin-protein ligase HECW1/2, N-terminal
Domain IPR037795 E3 ubiquitin-protein ligase HECW, C2 domain
Domain IPR040524 E3 ubiquitin-protein ligase HECW1, helical box domain
Homologous_superfamily IPR035892 C2 domain superfamily
Homologous_superfamily IPR035983 HECT, E3 ligase catalytic domain
Homologous_superfamily IPR036020 WW domain superfamily
Domain Details Per Protein
Protein Length C2 domain C2 domain superfamily E3 ubiquitin-protein ligase HECW1/2, N-terminal E3 ubiquitin-protein ligase HECW1, helical box domain E3 ubiquitin-protein ligase HECW, C2 domain HECT domain HECT, E3 ligase catalytic domain WW domain WW domain superfamily
UniProtKB:A0A2R8Q9I7 1508
UniProtKB:A0A286Y9W2 1475
UniProtKB:E9QIB6 1411
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations