ZFIN ID: ZDB-GENE-090302-2
Gene Name: adaptor related protein complex 2 subunit alpha 1
Gene Symbol: ap2a1    Nomenclature History

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Previous Names: fa95c07, si:ch211-195b15.3, wu:fa95c07 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have clathrin adaptor activity. Involved in dorsal/ventral axis specification and hematopoietic stem cell differentiation. Predicted to localize to AP-2 adaptor complex. Orthologous to human AP2A1 (adaptor related protein complex 2 subunit alpha 1).
Genome Resources: Alliance (1),  Gene:558153 (1),  Ensembl(GRCz11):ENSDARG00000054320 (2)
GENE EXPRESSION
All Expression Data: Fig. S7 from Umasankar et al., 2012
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1907 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9933 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20049 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20050 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20051 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26091 Point Mutation Unknown Splice Site ENU
    sa33213 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ap2a1 N/A 1
    MO2-ap2a1 N/A 1
    DISEASE ASSOCIATED WITH ap2a1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH ap2a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dorsal/ventral axis specification (more)
    Cellular Component AP-2 adaptor complex (more)
    Molecular Function clathrin adaptor activity (more)
    GO Terms (all 16)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ap2a1-201 (1)    Ensembl 1163
    ap2a1-203 (1)    Ensembl 5380
    ap2a1-204 (1)    Ensembl 590
    ap2a1-205 (1)    Ensembl 791
    ncRNA ap2a1-002 (1)    Ensembl 684
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ap2a1 No data available
    MARKER RELATIONSHIPS
    ap2a1 Contained in: [BAC] CH211-195B15 (1)
    ap2a1 Encodes: [EST] fa95c07
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005164062 (1)
    Genomic GenBank:CR936975 (1) 121737 nt
    Select Tool
    Polypeptide UniProtKB:X1WD71 (1) 959 aa
    Sequence Information (all 23)
    ORTHOLOGY for ap2a1 ( Chr: 3 )
    CITATIONS (24)