ZFIN ID: ZDB-GENE-090224-2
Gene Name: nectin cell adhesion molecule 1b
Gene Symbol: nectin1b    Nomenclature History

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Previous Names: nectin-1b (1), pvrl1b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have cell adhesion molecule binding activity and protein homodimerization activity. Predicted to be involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homophilic cell adhesion via plasma membrane adhesion molecules; and protein localization to cell junction. Predicted to localize to adherens junction. Is expressed in nervous system. Human ortholog(s) of this gene implicated in cleft lip; cleft lip-palate-ectodermal dysplasia syndrome; cleft palate; and ectodermal dysplasia. Orthologous to human NECTIN1 (nectin cell adhesion molecule 1).
Genome Resources: Alliance (1),  Gene:557665 (1),  Ensembl(GRCz11):ENSDARG00000086034 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020454Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nectin1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cleft lip-palate-ectodermal dysplasia syndrome Alliance Cleft lip/palate-ectodermal dysplasia syndrome 225060
    Orofacial cleft 7 225060
    DISEASE ASSOCIATED WITH nectin1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell adhesion (more)
    Cellular Component cell-cell junction (more)
    Molecular Function cell adhesion molecule binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nectin1b-202 (1)    Ensembl 1226
    ncRNA pvrl1b-002 (1) 641
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nectin1b No data available
    MARKER RELATIONSHIPS
    nectin1b Contained in: [BAC] CH73-322F14 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001167569 (1) 2561 nt
    Genomic GenBank:FP236505 (1) 110023 nt
    Select Tool
    Polypeptide UniProtKB:B0JYH6 (1) 541 aa
    Sequence Information (all 36)
    ORTHOLOGY for nectin1b ( Chr: 18 )
    CITATIONS (22)