ZFIN ID: ZDB-GENE-090115-1
Gene Name: diaphanous-related formin 2
Gene Symbol: diaph2    Nomenclature History

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Previous Names: zdia2 (1), diaphanous 2 (1), sb:eu1025 (1), si:dkeyp-11a1.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 14 Mapping Details/Browsers
Description: Predicted to have Rho GTPase binding activity and actin binding activity. Involved in cytoskeleton organization; gastrulation; and regulation of small GTPase mediated signal transduction. Is expressed in head. Human ortholog(s) of this gene implicated in premature ovarian failure. Orthologous to human DIAPH2 (diaphanous related formin 2).
Genome Resources: Alliance (1),  Gene:556029 (1),  Ensembl(GRCz11):ENSDARG00000076060 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu1025]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la019017Tg Transgenic Insertion Unknown Unknown DNA
la027555Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9480 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13059 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19092 Point Mutation Unknown Premature Stop ENU
    sa35741 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42431 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-diaph2 N/A 3
    MO2-diaph2 N/A 1
    DISEASE ASSOCIATED WITH diaph2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    premature ovarian failure Alliance ?Premature ovarian failure 2A 300511
    DISEASE ASSOCIATED WITH diaph2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Molecular Function actin binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA diaph2-202 (1)    Ensembl 7546
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM diaph2 No data available
    MARKER RELATIONSHIPS
    diaph2 Contained in: [BAC] CH73-264J12 (1), CH211-167L20 (1), CH211-235H23 (1), DKEY-12H12 (1) (order this), DKEY-152J20 (1) (order this), DKEY-221I2 (1) (order this), DKEYP-11A1 (1)
    [Fosmid] CH1073-454L7 (1)
    diaph2 Encodes: [EST] eu1025 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021472893 (1)
    Genomic GenBank:BX004990 (1) 201461 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1RCU7 (1) 1077 aa
    Sequence Information (all 36)
    ORTHOLOGY for diaph2 ( Chr: 14 )
    CITATIONS (22)