Gene

diaph2

ID
ZDB-GENE-090115-1
Name
diaphanous-related formin 2
Symbol
diaph2 Nomenclature History
Previous Names
  • zdia2 (1)
  • diaphanous 2 (1)
  • sb:eu1025 (1)
  • si:dkeyp-11a1.1
Type
protein_coding_gene
Location
Chr: 14 Mapping Details/Browsers
Description
Predicted to have Rho GTPase binding activity and actin binding activity. Involved in cytoskeleton organization; gastrulation; and regulation of small GTPase mediated signal transduction. Is expressed in head. Human ortholog(s) of this gene implicated in premature ovarian failure. Orthologous to human DIAPH2 (diaphanous related formin 2).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
10 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With diaph2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
primary ovarian insufficiency 2A Alliance ?Premature ovarian failure 2A 300511
Associated With diaph2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR010465 DRF autoregulatory
Domain IPR010472 Formin, FH3 domain
Domain IPR010473 Formin, GTPase-binding domain
Domain IPR014767 Diaphanous autoregulatory (DAD) domain
Domain IPR014768 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Domain IPR015425 Formin, FH2 domain
Family IPR027644 Protein diaphanous homologue 2
Homologous_superfamily IPR011989 Armadillo-like helical
Homologous_superfamily IPR016024 Armadillo-type fold
Homologous_superfamily IPR042201 Formin, FH2 domain superfamily
Domain Details Per Protein
Protein Length Armadillo-like helical Armadillo-type fold Diaphanous autoregulatory (DAD) domain DRF autoregulatory Formin, FH2 domain Formin, FH2 domain superfamily Formin, FH3 domain Formin, GTPase-binding domain Protein diaphanous homologue 2 Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
UniProtKB:A8DR44 499
UniProtKB:F1QPQ4 933
UniProtKB:F1RCU7 1077
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations