ZFIN ID: ZDB-GENE-081231-1
Gene Name: corticotropin releasing hormone receptor 1
Gene Symbol: crhr1    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Predicted to have G protein-coupled receptor activity; corticotropin-releasing hormone binding activity; and corticotropin-releasing hormone receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to localize to neuron projection and plasma membrane. Is expressed in griseum centrale and hindbrain. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; and obesity. Orthologous to several human genes including LINC02210-CRHR1 (LINC02210-CRHR1 readthrough).
Genome Resources: Alliance (1),  Gene:567940 (1),  Ensembl(GRCz11):ENSDARG00000003989 (2)
GENE EXPRESSION
All Expression Data: 5 figures from 4 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015120Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015122Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la028873Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2110 Point Mutation Unknown Splice Site ENU
    sa11535 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19989 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26049 Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    TALEN1-crhr1
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH crhr1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH crhr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell surface receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA crhr1-201 (1)    Ensembl 9998
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM crhr1 No data available
    MARKER RELATIONSHIPS
    crhr1 Contained in: [BAC] CH211-221H1 (1), DKEY-35A22 (1) (order this), DKEY-202K24 (1) (order this), DKEY-225I9 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_691254 (1) 4599 nt
    Genomic GenBank:BX547992 (1) 181320 nt
    Select Tool
    Polypeptide UniProtKB:X1WHD4 (1) 430 aa
    Sequence Information (all 12)
    ORTHOLOGY for crhr1 ( Chr: 3 )
    CITATIONS (31)