ZFIN ID: ZDB-GENE-081124-1
Gene Name: myosin, heavy chain b
Gene Symbol: myhb    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; actin filament binding activity; and motor activity. Predicted to localize to the myosin complex. Human ortholog(s) of this gene implicated in disease of cellular proliferation; distal arthrogryposis; and inclusion body myositis. Orthologous to human MYH2 (myosin heavy chain 2); MYH4 (myosin heavy chain 4); and MYH8 (myosin heavy chain 8).
Genome Resources: Alliance (1),  Gene:100002040 (1),  Ensembl(GRCz11):ENSDARG00000001993 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17247 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18118 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25345 Point Mutation Unknown Premature Stop ENU
    sa31534 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH myhb HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH myhb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component myosin complex (more)
    Molecular Function actin binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Binding_site IPR000048 IQ motif, EF-hand binding site
    Domain IPR001609 Myosin head, motor domain
    Domain IPR002928 Myosin tail
    Domain IPR004009 Myosin, N-terminal, SH3-like
    Homologous_superfamily IPR008989 Myosin S1 fragment, N-terminal
    Homologous_superfamily IPR027401 Myosin IQ motif-containing domain superfamily
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA myhb-202 (1)    Ensembl 5998
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM myhb No data available
    MARKER RELATIONSHIPS
    myhb Contained in: [BAC] CH211-157B11 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001339170 (1) 5988 bp
    Genomic GenBank:CR450814 (1) 158142 bp
    Select Tool
    Polypeptide UniProtKB:F1QVX3 (1) 1937 aa
    Sequence Information (all 10)
    ORTHOLOGY for myhb ( Chr: 6 )
    CITATIONS (22)