ZFIN ID: ZDB-GENE-081119-3
Gene Name: FRAS1 related extracellular matrix 2a
Gene Symbol: frem2a    Nomenclature History

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Previous Names: bla (1), blasen (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Involved in fin morphogenesis. Predicted to localize to integral component of membrane. Is expressed in fin; fin fold pectoral fin bud; median fin fold; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2).
Genome Resources: Alliance (1),  Gene:555681 (1),  Ensembl(GRCz11):ENSDARG00000076856 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa2557 Point Mutation Unknown Premature Stop ENU
sa5585 Point Mutation Unknown Premature Stop ENU
sa14672 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16135 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17334 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21742 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21743 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24874 Point Mutation Unknown Premature Stop ENU
    sa41667 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ta90 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-frem2a N/A 1
    DISEASE ASSOCIATED WITH frem2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Fraser syndrome 2 Alliance Fraser syndrome 2 617666
    isolated cryptophthalmia Alliance Cryptophthalmos, unilateral or bilateral, isolated 123570
    DISEASE ASSOCIATED WITH frem2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fin development (more)
    Cellular Component integral component of membrane (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA frem2a-201 (1)    Ensembl 9873
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM frem2a No data available
    MARKER RELATIONSHIPS
    frem2a Contained in: [BAC] CH211-210L19 (1), DKEY-3L17 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001137657 (1) 9342 nt
    Genomic GenBank:BX530083 (1) 155046 nt
    Select Tool
    Polypeptide UniProtKB:D7PS91 (1) 3119 aa
    Sequence Information (all 15)
    ORTHOLOGY for frem2a ( Chr: 10 )
    CITATIONS (26)