Gene

frem2a

ID
ZDB-GENE-081119-3
Name
FRAS1 related extracellular matrix 2a
Symbol
frem2a Nomenclature History
Previous Names
  • bla (1)
  • blasen (1)
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Involved in fin morphogenesis. Predicted to localize to integral component of membrane. Is expressed in fin; fin fold pectoral fin bud; median fin fold; pharyngeal arch; and trunk. Human ortholog(s) of this gene implicated in Fraser syndrome 2 and isolated cryptophthalmia. Orthologous to human FREM2 (FRAS1 related extracellular matrix 2).
Genome Resources
Note
None
Expression
All Expression Data
4 figures from 3 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With frem2a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fraser syndrome 2 Alliance Fraser syndrome 2 617666
isolated cryptophthalmia Alliance Cryptophthalmos, unilateral or bilateral, isolated 123570
Associated With frem2a Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003644 Na-Ca exchanger/integrin-beta4
Homologous_superfamily IPR038081 CalX-like domain superfamily
Repeat IPR039005 CSPG repeat
Domain Details Per Protein
Protein Length CalX-like domain superfamily CSPG repeat Na-Ca exchanger/integrin-beta4
UniProtKB:F6NHY4 3110
UniProtKB:D7PS91 3119
UniProtKB:B6IDE6 3113
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations