ZFIN ID: ZDB-GENE-081114-1
Gene Name: phosphofructokinase, muscle b
Gene Symbol: pfkmb    Nomenclature History

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Previous Names: im:7137110, wu:fc58g11 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have several functions, including 6-phosphofructokinase activity; adenyl ribonucleotide binding activity; and fructose-6-phosphate binding activity. Predicted to be involved in several processes, including canonical glycolysis; fructose 1,6-bisphosphate metabolic process; and protein homotetramerization. Predicted to localize to 6-phosphofructokinase complex and membrane. Human ortholog(s) of this gene implicated in glycogen storage disease VII. Orthologous to human PFKM (phosphofructokinase, muscle).
Genome Resources: Alliance (1),  Gene:568001 (1),  Ensembl(GRCz11):ENSDARG00000060797 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [IMAGE:7137110]
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa31530 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH pfkmb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    glycogen storage disease VII Alliance Glycogen storage disease VII 232800
    DISEASE ASSOCIATED WITH pfkmb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fructose 6-phosphate metabolic process (more)
    Cellular Component cytoplasm (more)
    Molecular Function 6-phosphofructokinase activity (more)
    GO Terms (all 22)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pfkmb-201 (1)    Ensembl 2743
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pfkmb No data available
    MARKER RELATIONSHIPS
    pfkmb Contained in: [BAC] CH211-233B16 (1)
    pfkmb Encodes: [EST] fc58g11, IMAGE:7137110 (1)
    [cDNA] MGC:162168 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001089417 (1) 2723 nt
    Genomic GenBank:AL954698 (1) 177161 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RZX5 (1) 805 aa
    Sequence Information (all 22)
    ORTHOLOGY for pfkmb ( Chr: 6 )
    CITATIONS (28)