ZFIN ID: ZDB-GENE-081107-52
Gene Name: SMG6 nonsense mediated mRNA decay factor
Gene Symbol: smg6    Nomenclature History

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Previous Name: si:dkey-16f21.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have telomerase RNA binding activity and telomeric DNA binding activity. Involved in chordate embryonic development and nuclear-transcribed mRNA catabolic process, nonsense-mediated decay. Predicted to localize to cytoplasm and telomerase holoenzyme complex. Orthologous to human SMG6 (SMG6 nonsense mediated mRNA decay factor).
Genome Resources: Alliance (1),  Gene:100334020 (1),  Ensembl(GRCz11):ENSDARG00000100481 (1)
GENE EXPRESSION
All Expression Data: 2 figures from Wittkopp et al., 2009
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa17851 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41704 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-smg6 N/A 1
    MO2-smg6 N/A 1
    DISEASE ASSOCIATED WITH smg6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH smg6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (more)
    Cellular Component cytoplasm (more)
    Molecular Function transferase activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA smg6-201 (1)    Ensembl 5701
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM smg6 No data available
    MARKER RELATIONSHIPS
    smg6 Contained in: [BAC] CH211-89O5 (1), CH211-102B8 (1), CH211-151F2 (1), DKEY-16F21 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005172741 (1)
    Genomic GenBank:BX663516 (1) 183367 nt
    Select Tool
    Polypeptide UniProtKB:A0A0R4IZ84 (1) 1544 aa
    Sequence Information (all 12)
    ORTHOLOGY for smg6 ( Chr: 10 )
    CITATIONS (17)