ZFIN ID: ZDB-GENE-081107-40
Gene Name: PROP paired-like homeobox 1
Gene Symbol: prop1    Nomenclature History

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Previous Name: si:ch211-93n23.5 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in adenohypophysis development. Predicted to localize to nucleus. Is expressed in hypophysis. Human ortholog(s) of this gene implicated in hypogonadism; hypopituitarism; and panhypopituitarism. Orthologous to human PROP1 (PROP paired-like homeobox 1).
Genome Resources: Alliance (1),  Gene:100001377 (1),  Ensembl(GRCz11):ENSDARG00000039756 (1)
GENE EXPRESSION
All Expression Data: 2 figures from Angotzi et al., 2011
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-prop1 N/A 1
DISEASE ASSOCIATED WITH prop1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
hypopituitarism Alliance Pituitary hormone deficiency, combined, 2 262600
DISEASE ASSOCIATED WITH prop1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process adenohypophysis development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA prop1-201 (1)    Ensembl 832
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM prop1 No data available
MARKER RELATIONSHIPS
prop1 Contained in: [BAC] CH211-93N23 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001177461 (1)
Genomic GenBank:BX004962 (1) 170736 nt
Select Tool
Polypeptide UniProtKB:F6PE50 (1) 242 aa
Sequence Information (all 9)
ORTHOLOGY for prop1 ( Chr: 13 )
CITATIONS (18)