ZFIN ID: ZDB-GENE-081105-73
Gene Name: IQ motif and Sec7 domain ArfGEF 2b
Gene Symbol: iqsec2b    Nomenclature History

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Previous Names: iqsec2, si:ch211-218o21.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have ARF guanyl-nucleotide exchange factor activity. Predicted to be involved in actin cytoskeleton organization. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000077709 (2)
GENE EXPRESSION No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH iqsec2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability Alliance Mental retardation, X-linked 1/78 309530
DISEASE ASSOCIATED WITH iqsec2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process regulation of ARF protein signal transduction (more)
Molecular Function ARF guanyl-nucleotide exchange factor activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA iqsec2b-202 (1)    Ensembl 4120
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM iqsec2b No data available
MARKER RELATIONSHIPS
iqsec2b Contained in: [BAC] CH211-218O21 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
Genomic GenBank:BX537348 (1) 207282 nt Blast at MegaBLAST
Polypeptide UniProtKB:E9QDV4 (1) 1520 aa
Sequence Information (all 4)
ORTHOLOGY for iqsec2b ( Chr: 8 )
CITATIONS (12)