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Gene

iqsec2b

ID
ZDB-GENE-081105-73
Name
IQ motif and Sec7 domain ArfGEF 2b
Symbol
iqsec2b Nomenclature History
Previous Names
  • iqsec2
  • si:ch211-218o21.3
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to be involved in actin cytoskeleton organization. Predicted to act upstream of or within regulation of ARF protein signal transduction. Predicted to be located in cytoplasm. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 1. Orthologous to human IQSEC2 (IQ motif and Sec7 domain ArfGEF 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With iqsec2b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
non-syndromic X-linked intellectual disability 1 Alliance Intellectual developmental disorder, X-linked 1 309530
Associated With iqsec2b Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR000048 IQ motif, EF-hand binding site
Domain IPR000904 Sec7 domain
Domain IPR001849 Pleckstrin homology domain
Domain IPR033742 IQ motif and SEC7 domain-containing protein, PH domain
Homologous_superfamily IPR011993 PH-like domain superfamily
Homologous_superfamily IPR023394 Sec7, C-terminal domain superfamily
Homologous_superfamily IPR035999 Sec7 domain superfamily
Domain Details Per Protein
Protein Length IQ motif and SEC7 domain-containing protein, PH domain IQ motif, EF-hand binding site PH-like domain superfamily Pleckstrin homology domain Sec7, C-terminal domain superfamily Sec7 domain Sec7 domain superfamily
UniProtKB:A0A2R8Q8I6 1374
UniProtKB:E9QDV4 1520
UniProtKB:F1R952 1373
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations