Gene

fmnl2a

ID

ZDB-GENE-081105-70

Name

formin-like 2a

Symbol

fmnl2a Nomenclature History

Previous Names

fmnl2
si:ch211-279a7.1

Type

protein_coding_gene

Location

Chr: 9 Mapping Details/Browsers

Description

Predicted to have actin filament binding activity. Predicted to be involved in cell migration; cortical actin cytoskeleton organization; and regulation of cell shape. Predicted to localize to cytosol. Is expressed in several structures, including blood vessel; nervous system; neuroectoderm; optic cup; and polster. Orthologous to human FMNL2 (formin like 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

8 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fmnl2a Human Ortholog

No data available

Associated With fmnl2a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR010472	Formin, FH3 domain
Domain	IPR010473	Formin, GTPase-binding domain
Domain	IPR014767	Diaphanous autoregulatory (DAD) domain
Domain	IPR014768	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
Domain	IPR015425	Formin, FH2 domain
Family	IPR027656	Formin-like protein 2
Family	IPR043592	Formin-like protein, animal
Homologous_superfamily	IPR011989	Armadillo-like helical
Homologous_superfamily	IPR016024	Armadillo-type fold
Homologous_superfamily	IPR042201	Formin, FH2 domain superfamily

Domain Details Per Protein

Protein	Length	Armadillo-like helical	Armadillo-type fold	Diaphanous autoregulatory (DAD) domain	Formin, FH2 domain	Formin, FH2 domain superfamily	Formin, FH3 domain	Formin, GTPase-binding domain	Formin-like protein 2	Formin-like protein, animal	Rho GTPase-binding/formin homology 3 (GBD/FH3) domain
UniProtKB:F1QDA5 InterPro	1088
UniProtKB:F1QKR1 InterPro	1077
UniProtKB:F1Q6D2 InterPro	521

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Length (nt)	Analysis
mRNA	fmnl2a-201 (1) Ensembl	3267 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	fmnl2a-202 (1) Ensembl	4842 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	fmnl2a-203 (1) Ensembl	3659 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations