ZFIN ID: ZDB-GENE-050119-6
Gene Name: large tumor suppressor kinase 2
Gene Symbol: lats2    Nomenclature History

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Previous Name: si:ch211-173o4.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have protein serine/threonine kinase activity. Involved in BMP signaling pathway; convergent extension involved in gastrulation; and secondary heart field specification. Is expressed in several structures, including nervous system; neural crest cell; non neural ectoderm; pectoral fin bud; and pleuroperitoneal region. Orthologous to human LATS2 (large tumor suppressor kinase 2).
Genome Resources: Alliance (1),  Gene:567674 (1),  Ensembl(GRCz11):ENSDARG00000078864 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la026802Tg Transgenic Insertion Unknown Unknown DNA
la029554Tg Transgenic Insertion Unknown Unknown DNA
mw87 Small Deletion Unknown Unknown CRISPR
ncv108 Small Deletion Exon 3 Frameshift, Premature Stop TALEN
sa7627 Point Mutation Unknown Missense ENU
sa34612 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38734 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38735 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lats2 1
    CRISPR2-lats2 1
    MO1-lats2 N/A 1
    MO2-lats2 N/A 5
    TALEN1-lats2 1
    DISEASE ASSOCIATED WITH lats2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH lats2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process BMP signaling pathway (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008271 Serine/threonine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR000719 Protein kinase domain
    Domain IPR000961 AGC-kinase, C-terminal
    Domain IPR015940 Ubiquitin-associated domain
    Family IPR028742 Serine/threonine-protein kinase LATS2
    Homologous_superfamily IPR009060 UBA-like superfamily
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA lats2-204 (1)    Ensembl 3922
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lats2 No data available
    MARKER RELATIONSHIPS
    lats2 Contained in: [BAC] CH211-173O4 (1), RP71-68N21 (1)
    lats2 Encodes: [STS] zfish44906-4818b06.p1k
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001123307 (1)
    Genomic GenBank:BX511129 (1) 152922 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QF71 (1) 1140 aa
    Sequence Information (all 22)
    ORTHOLOGY for lats2 ( Chr: 9 )
    CITATIONS (28)