ZFIN ID: ZDB-GENE-081105-56
Gene Name: lysine (K)-specific demethylase 6A
Gene Symbol: kdm6a    Nomenclature History

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Previous Names: si:ch211-222m21.1, utx-a (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone demethylase activity (H3-K27 specific). Involved in several processes, including embryonic morphogenesis; face development; and germ cell migration. Predicted to localize to MLL3/4 complex and nuclear chromatin. Is expressed in several structures, including blood island; ethmoid cartilage; otic vesicle; pharyngeal arch; and pronephric duct. Used to study Kabuki syndrome. Human ortholog(s) of this gene implicated in Kabuki syndrome; acute lymphoblastic leukemia; and esophagus squamous cell carcinoma. Orthologous to several human genes including KDM6A (lysine demethylase 6A).
Genome Resources: Alliance (1),  Gene:569277 (1),  Ensembl(GRCz11):ENSDARG00000061759 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010166Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026932Tg Transgenic Insertion Unknown Unknown DNA
    la026933Tg Transgenic Insertion Unknown Unknown DNA
    la029585Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7197 Point Mutation Unknown Premature Stop ENU
    sa17907 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34686 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kdm6a
    3
    MO1-kdm6a N/A 2
    MO2-kdm6a N/A 3
    MO3-kdm6a N/A 1
    MO4-kdm6a N/A 1
    DISEASE ASSOCIATED WITH kdm6a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Kabuki syndrome Alliance Kabuki syndrome 2 300867
    DISEASE ASSOCIATED WITH kdm6a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Kabuki syndrome EKW + MO2-kdm6a standard conditions Tsai et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Cellular Component MLL3/4 complex (more)
    Molecular Function chromatin binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdm6a-203 (1)    Ensembl 5041
    ncRNA kdm6a-002 (1) 847
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm6a No data available
    MARKER RELATIONSHIPS
    kdm6a Contained in: [BAC] CH73-147F11 (1), CH211-222M21 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005167794 (1) 5812 nt
    Genomic GenBank:BX572627 (1) 209758 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q597 (1) 1452 aa
    Sequence Information (all 17)
    ORTHOLOGY for kdm6a ( Chr: 9 )
    CITATIONS (30)