ZFIN ID: ZDB-GENE-081105-56
Gene Name: lysine (K)-specific demethylase 6A
Gene Symbol: kdm6a
Sequence Ontology ID : SO:0000704

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Previous Names: si:ch211-222m21.1, utx-a (1)

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(Including Attributions)
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have RNA polymerase II proximal promoter sequence-specific DNA binding activity, chromatin DNA binding activity, and histone demethylase activity (H3-K27 specific); involved in several  ...
GENE EXPRESSION
All Expression Data: 4 figures from 4 publications
Wild-type Stages, Structures: Segmentation:26+ somites (22.0h-24.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la010166Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la026932Tg Transgenic Insertion Unknown Unknown DNA
    la026933Tg Transgenic Insertion Unknown Unknown DNA
    la029585Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7197 Point Mutation Unknown Premature Stop ENU
    sa17907 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34686 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 11 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH kdm6a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Kabuki syndrome Kabuki syndrome 2 300867
    DISEASE ASSOCIATED WITH kdm6a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Kabuki syndrome EKW + MO2-kdm6a standard conditions Tsai et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process brain development (more)
    Molecular Function histone demethylase activity (H3-K27 specific) (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003347 (1)
  • InterPro:IPR011990 (1)
  • InterPro:IPR013026 (1)
  • InterPro:IPR019734 (1)
  • InterPro:IPR029516 (1)
  • PROSITE:PS50005 (1)
  • PROSITE:PS50293 (1)
  • PROSITE:PS51184 (1)
  • Pfam:PF02373 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA kdm6a-002 (1) 847
    mRNA kdm6a-203 (1) 5041
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM kdm6a No data available
    MARKER RELATIONSHIPS
    kdm6aContained in: [BAC] CH73-147F11 (1) (order this), CH211-222M21 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_005167794 (1) 5812bp
    Genomic GenBank:BX572627 (1) 209758bp Blast at MegaBLAST
    Polypeptide UniProtKB:F1Q597 (1) 1452aa
    Sequence Clusters UniGene:107641 (1)
    Sequence Information (all 18)
    OTHER kdm6a GENE PAGES
  • Alliance (1)
  • Gene:569277 (1)
  • VEGA:OTTDARG00000029362 (1)
  • Ensembl(GRCz11):ENSDARG00000061759 (2)
  • ORTHOLOGY for kdm6a (Chr: 9)
    CITATIONS (28)