ZFIN ID: ZDB-GENE-081105-44
Gene Name: mitofusin 2
Gene Symbol: mfn2    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: mg:cb01g09, si:dkeyp-104h9.2, wu:fb79a11

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have GTPase activity. Involved in several processes, including axonal transport of mitochondrion; axonogenesis; and neuromuscular junction development. Predicted to localize to the intrinsic component of mitochondrial outer membrane. Used to study Charcot-Marie-Tooth disease type 2. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2; and Charcot-Marie-Tooth disease type 6. Is expressed in several structures, including gut; heart; nervous system; otic vesicle; and ventral mesenchyme. Orthologous to human MFN2 (mitofusin 2).
Genome Resources: Alliance (1),  Gene:567448 (1),  Ensembl(GRCz11):ENSDARG00000079504 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Cleavage:2-cell (0.75h-1.0h) to Larval:Day 4 (96.0h-120.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3528 Point Mutation Exon 8 Premature Stop ENU
la026611Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa13351 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21386 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34491 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-mfn2 N/A 2
    MO2-mfn2 N/A 1
    DISEASE ASSOCIATED WITH mfn2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease type 2A2A Alliance Charcot-Marie-Tooth disease, axonal, type 2A2A 609260
    Charcot-Marie-Tooth disease type 2A2B Alliance Charcot-Marie-Tooth disease, axonal, type 2A2B 617087
    Charcot-Marie-Tooth disease type 6 Alliance Hereditary motor and sensory neuropathy VIA 601152
    DISEASE ASSOCIATED WITH mfn2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Charcot-Marie-Tooth disease type 2 ml2Tg + MO1-mfn2 standard conditions Vettori et al., 2011
    WT + MO1-mfn2 standard conditions Vettori et al., 2011
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonal transport of mitochondrion (more)
    Cellular Component integral component of membrane (more)
    Molecular Function GTPase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR006884 Fzo/mitofusin HR2 domain
    Family IPR022812 Dynamin superfamily
    Family IPR027089 Mitofusin-2
    Family IPR027094 Mitofusin family
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Domain IPR030381 Dynamin-type guanine nucleotide-binding (G) domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mfn2-201 (1)    Ensembl 5369
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mfn2 No data available
    MARKER RELATIONSHIPS
    mfn2 Contained in: [BAC] DKEYP-104H9 (1)
    mfn2 Contains: [SNP] rs3728186 (1)
    mfn2 Encodes: [EST] cb01g09, fb79a11
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001128254 (1) 2316 bp
    Genomic GenBank:BX548250 (1) 165603 bp
    Select Tool
    Polypeptide UniProtKB:A8WIN6 (1) 757 aa
    Sequence Information (all 18)
    ORTHOLOGY for mfn2 ( Chr: 8 )
    CITATIONS (40)