ZFIN ID: ZDB-GENE-081105-182
Gene Name: endothelin receptor type Bb
Gene Symbol: ednrbb    Nomenclature History

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Previous Names: ednrb1b, si:ch211-72k22.4 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have endothelin receptor activity. Predicted to be involved in several processes, including enteric nervous system development; regulation of blood pressure; and vasoconstriction. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in ABCD syndrome; Hirschsprung's disease; Waardenburg's syndrome (multiple); asthma; and pulmonary hypertension. Orthologous to human EDNRB (endothelin receptor type B).
Genome Resources: Alliance (1),  Gene:560081 (1),  Ensembl(GRCz11):ENSDARG00000053498 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13240 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-ednrbb N/A 1
    PHENOTYPE
    Data: Fig. S7 from Tilghman et al., 2019
    Observed in:
    DISEASE ASSOCIATED WITH ednrbb HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ABCD syndrome Alliance ABCD syndrome 600501
    Waardenburg syndrome type 4A Alliance Waardenburg syndrome, type 4A 277580
    {Hirschsprung disease, susceptibility to, 2} 600155
    DISEASE ASSOCIATED WITH ednrbb VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process enteric nervous system development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function endothelin receptor activity (more)
    GO Terms (all 9)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000276 G protein-coupled receptor, rhodopsin-like
    Family IPR000499 Endothelin receptor family
    Family IPR001112 Endothelin receptor B
    Domain IPR017452 GPCR, rhodopsin-like, 7TM
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ednrbb-202 (1)    Ensembl 1351
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ednrbb No data available
    MARKER RELATIONSHIPS
    ednrbb Contained in: [BAC] CH211-72K22 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_683473 (1)
    Genomic GenBank:BX248504 (1) 178247 bp
    Select Tool
    Polypeptide UniProtKB:F8W4E0 (1) 365 aa
    Sequence Information (all 6)
    ORTHOLOGY for ednrbb ( Chr: 9 )
    CITATIONS (13)