Gene
plekha2
- ID
- ZDB-GENE-081105-163
- Name
- pleckstrin homology domain containing A2
- Symbol
- plekha2 Nomenclature History
- Previous Names
-
- si:ch211-204d2.4
- Type
- protein_coding_gene
- Location
- Chr: 8 Mapping Details/Browsers
- Description
- Predicted to enable phosphatidylinositol-3,4-bisphosphate binding activity and phospholipid binding activity. Predicted to be active in cytoplasm and plasma membrane. Orthologous to human PLEKHA2 (pleckstrin homology domain containing A2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| la029422Tg | Transgenic insertion | Unknown | Unknown | DNA | |
| sa21208 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa34317 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa34318 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | PH-like domain superfamily | Phosphoinositide-Interacting Signal Transduction Regulators | Pleckstrin homology domain |
|---|---|---|---|---|---|
| UniProtKB:A0A8M2BE46 | InterPro | 391 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
si:ch211-204d2.4-201
(1)
|
Ensembl | 1,340 nt |
Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | CH211-204D2 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001128363 (1) | |||
| Genomic | GenBank:CR847826 (1) | 150519 nt | ||
| Polypeptide | UniProtKB:A0A8M2BE46 (1) | 391 aa |
- Comparative Orthology
- Alliance
- Varshney, G.K., Lu, J., Gildea, D., Huang, H., Pei, W., Yang, Z., Huang, S.C., Schoenfeld, D.S., Pho, N., Casero, D., Hirase, T., Mosbrook-Davis, D.M., Zhang, S., Jao, L.E., Zhang, B., Woods, I.G., Zimmerman, S., Schier, A.F., Wolfsberg, T., Pellegrini, M., Burgess, S.M., and Lin, S. (2013) A large-scale zebrafish gene knockout resource for the genome-wide study of gene function. Genome research. 23(4):727-735
- Wang, D., Jao, L.E., Zheng, N., Dolan, K., Ivey, J., Zonies, S., Wu, X., Wu, K., Yang, H., Meng, Q., Zhu, Z., Zhang, B., Lin, S., and Burgess, S.M. (2007) Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions. Proceedings of the National Academy of Sciences of the United States of America. 104(30):12428-12433
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