ZFIN ID: ZDB-GENE-081105-16
Gene Name: phosphodiesterase 4D, cAMP-specific
Gene Symbol: pde4d    Nomenclature History

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Previous Name: si:dkey-190g11.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in signal transduction. Is expressed in brain; female organism; and head. Human ortholog(s) of this gene implicated in acrodysostosis. Orthologous to human PDE4D (phosphodiesterase 4D).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000032761 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Larval:Protruding-mouth (72.0h-96.0h, 3.5mm) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la029434Tg Transgenic Insertion Unknown Unknown DNA
la029435Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa117 Point Mutation Unknown Premature Stop ENU
    sa9416 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14598 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18915 Point Mutation Unknown Premature Stop ENU
    sa41163 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45318 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pde4d N/A 1
    MO2-pde4d N/A 1
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH pde4d HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acrodysostosis Alliance Acrodysostosis 2, with or without hormone resistance 614613
    DISEASE ASSOCIATED WITH pde4d VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process signal transduction (more)
    Molecular Function 3',5'-cyclic-nucleotide phosphodiesterase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pde4d-202 (1)    Ensembl 1993
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pde4d No data available
    MARKER RELATIONSHIPS
    pde4d Contained in: [BAC] DKEY-190G11 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:BX510928 (1) 197947 nt
    Select Tool
    Polypeptide UniProtKB:F1Q5E8 (1) 703 aa
    Sequence Information (all 3)
    ORTHOLOGY for pde4d ( Chr: 8 )
    CITATIONS (23)