ZFIN ID: ZDB-GENE-081105-14
Gene Name: kinesin family member 5C
Gene Symbol: kif5c    Nomenclature History

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Previous Name: si:ch211-157c24.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have ATP-dependent microtubule motor activity, plus-end-directed and microtubule binding activity. Predicted to be involved in anterograde dendritic transport of neurotransmitter receptor complex; axon guidance; and synaptic vesicle transport. Predicted to localize to the kinesin complex and microtubule. Human ortholog(s) of this gene implicated in complex cortical dysplasia with other brain malformations 2 and schizophrenia. Is expressed in gonad; immature eye; nervous system; otic vesicle; and trigeminal placode. Orthologous to human KIF5C (kinesin family member 5C).
Genome Resources: Alliance (1),  Gene:565563 (1),  Ensembl(GRCz11):ENSDARG00000076027 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a291 Complex Unknown Unknown CRISPR
sa5538 Point Mutation Unknown Premature Stop ENU
sa8541 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa9450 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21480 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34632 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa38739 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kif5c 1
    CRISPR2-kif5c 1
    CRISPR3-kif5c 1
    CRISPR4-kif5c 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kif5c HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    complex cortical dysplasia with other brain malformations 2 Alliance Cortical dysplasia, complex, with other brain malformations 2 615282
    DISEASE ASSOCIATED WITH kif5c VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process microtubule-based movement (more)
    Cellular Component microtubule (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR019821 Kinesin motor domain, conserved site
    Domain IPR001752 Kinesin motor domain
    Family IPR027640 Kinesin-like protein
    Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Homologous_superfamily IPR036961 Kinesin motor domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kif5c-201 (1)    Ensembl 3304
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kif5c No data available
    MARKER RELATIONSHIPS
    kif5c Contained in: [BAC] CH211-157C24 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001123275 (1) 3304 nt
    Genomic GenBank:BX936418 (1) 119085 nt
    Select Tool
    Polypeptide UniProtKB:B0S8J1 (1) 985 aa
    Sequence Information (all 7)
    ORTHOLOGY for kif5c ( Chr: 9 )
    CITATIONS (20)