ZFIN ID: ZDB-GENE-081105-114
Gene Name: collagen, type IV, alpha 1
Gene Symbol: col4a1    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: fj65e07, im:7157877 (1), si:ch211-174g17.1 (1), wu:fj65e07 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have extracellular matrix structural constituent. Predicted to be involved in growth plate cartilage chondrocyte morphogenesis. Predicted to localize to collagen-containing extracellular matrix and extracellular space. Is expressed in several structures, including cardiovascular system; eye; hypodermis; optic fissure; and paraxial mesoderm. Human ortholog(s) of this gene implicated in COL4A1-related familial vascular leukoencephalopathy; myocardial infarction; and retinal arterial tortuosity. Orthologous to human COL4A1 (collagen type IV alpha 1 chain).
Genome Resources: Alliance (1),  Gene:554269 (1),  Ensembl(GRCz11):ENSDARG00000055009 (2)
GENE EXPRESSION
All Expression Data: 11 figures from 5 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [IMAGE:7157877]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
col4a1_unrecovered Point Mutation Unknown Unknown ENU
fh336 Point Mutation Unknown Unknown ENU
sa16923 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21437 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27345 Point Mutation Unknown Premature Stop ENU
    sa34559 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34560 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41357 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45346 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • st93 Small Deletion Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-col4a1
    1
    CRISPR2-col4a1
    1
    CRISPR3-col4a1
    1
    MO1-col4a1 N/A 1
    TALEN1-col4a1 1
    DISEASE ASSOCIATED WITH col4a1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    COL4A1-related familial vascular leukoencephalopathy Alliance Brain small vessel disease with or without ocular anomalies 175780
    retinal arterial tortuosity Alliance ?Retinal arteries, tortuosity of 180000
    Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 611773
    Microangiopathy and leukoencephalopathy, pontine, autosomal dominant 618564
    {Hemorrhage, intracerebral, susceptibility to} 614519
    DISEASE ASSOCIATED WITH col4a1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component basement membrane (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA col4a1-201 (1)    Ensembl 5961
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM col4a1 No data available
    MARKER RELATIONSHIPS
    col4a1 Contained in: [BAC] CH73-182O2 (1), CH211-174G17 (1)
    col4a1 Encodes: [EST] fj65e07, IMAGE:7157877 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_688948 (1) 7341 nt
    Genomic GenBank:FP103004 (1) 87932 nt
    Select Tool
    Polypeptide UniProtKB:F1Q8S5 (1) 1583 aa
    Sequence Information (all 26)
    ORTHOLOGY for col4a1 ( Chr: 9 )
    CITATIONS (31)