ZFIN ID: ZDB-GENE-081105-114
Gene Name: collagen, type IV, alpha 1
Gene Symbol: col4a1
Sequence Ontology ID : SO:0000704

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Previous Names: fj65e07, im:7157877 (1), si:ch211-174g17.1 (1), wu:fj65e07 (1)

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Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 9 figures from 4 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [IMAGE:7157877]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
  cardiovascular system, hypodermis, paraxial mesoderm, vasculature basement membrane (all 5) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
col4a1_unrecovered Point Mutation Unknown Unknown ENU
fh336 Point Mutation Unknown Unknown ENU
sa16923 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21437 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27345 Point Mutation Unknown Premature Stop ENU
    sa34559 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa34560 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41357 Point Mutation Unknown Splice Site ENU
    st93 Small Deletion Unknown Unknown TALEN
    Targeting reagents: MO1-col4a1 (1), TALEN1-col4a1 (1)
    PHENOTYPE
    Data: Fig. 6 from Stratman et al., 2017
    Observed in: dorsal aorta, dorsal aorta morphogenesis
    DISEASE ASSOCIATED WITH col4a1 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    COL4A1-related familial vascular leukoencephalopathy Brain small vessel disease with or without ocular anomalies 607595
    porencephaly Porencephaly 1 175780
    ?Retinal arteries, tortuosity of 180000
    Angiopathy, hereditary, with nephropathy, aneurysms, and muscle cramps 611773
    {Hemorrhage, intracerebral, susceptibility to} 614519
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component basement membrane (more)
    Molecular Function extracellular matrix structural constituent (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001442 (1)
  • InterPro:IPR008160 (1)
  • InterPro:IPR016187 (1)
  • PROSITE:PS51403 (1)
  • Pfam:PF01391 (1)
  • Pfam:PF01413 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA col4a1-001 (1) 5961
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM col4a1 No data available
    MARKER RELATIONSHIPS
    col4a1Contained in: [BAC] CH73-182O2 (1) (order this), CH211-174G17 (1) (order this)
    col4a1Encodes: [EST] fj65e07, IMAGE:7157877 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_688948 (1) 7341bp
    Genomic GenBank:FP103004 (1) 87932bp
    Select Tool
    Polypeptide UniProtKB:F1Q8S5 (1) 1583aa
    Sequence Clusters UniGene:117044 (1)
    Sequence Information (all 30)
    OTHER col4a1 GENE PAGES
  • Alliance (1)
  • Gene:554269 (1)
  • VEGA:OTTDARG00000029009 (1)
  • Ensembl(GRCz10):ENSDARG00000055009 (1)
  • ORTHOLOGY for col4a1 (Chr: 9)
    CITATIONS (24)