Community Action Needed: Please respond to the NIH RFI
Gene

bub1

ID
ZDB-GENE-081104-75
Name
BUB1 mitotic checkpoint serine/threonine kinase
Symbol
bub1 Nomenclature History
Previous Names
  • si:ch1073-192f24.1
Type
protein_coding_gene
Location
Chr: 20 Mapping Details/Browsers
Description
Predicted to enable protein kinase activity. Predicted to be involved in meiotic sister chromatid cohesion, centromeric and mitotic spindle assembly checkpoint signaling. Predicted to act upstream of or within protein phosphorylation. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human BUB1 (BUB1 mitotic checkpoint serine/threonine kinase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bub1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
colorectal cancer Alliance Colorectal cancer with chromosomal instability, somatic 114500
Associated With bub1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Domain IPR000719 Protein kinase domain
Domain IPR013212 Mad3/Bub1 homology region 1
Family IPR015661 Mitotic spindle checkpoint protein Bub1/Mad3
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Mad3/Bub1 homology region 1 Mitotic spindle checkpoint protein Bub1/Mad3 Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site
UniProtKB:A0A2R8QQZ9 202
UniProtKB:F1QNS6 1202
UniProtKB:B0VJZ8 305
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations